📹OUT NOW, our visual article in JoVE Journal!
We present a protocol to enable the capture & identification of disease-specific protein-protein interactions from native cells & tissues using chemical probes & mass spectrometry app.jove.com/v/69197/ #Proteomics #SystemsBiology #NetworkBiology #dfPPI
'Mapping Epichaperome-Driven Network Dysfunctions in Alzheimer’s Disease Using Dysfunctional Protein-Protein Interactome Analysis' presented by Dr. Anna Rodina at #SfN25!
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Thank you to everyone engaged with our work & Anna for giving a superb presentation!
#dfPPI #epichaperome #alzheimers #omics
📸OUT NOW in JoVE Journal: Mapping Dysfunctional Protein-Protein Interactions in Disease.
Our method article is available now with video component coming soon!
app.jove.com/t/69197
#PPI #networkbiology #cancerbiology #dfPPI #MassSpectrometry #Proteomics
🔗 Protein connectivity changes detected by dfPPI show minimal correlation with overall protein expression—demonstrating the need to look beyond protein levels to understand true disease biology. #Proteomics #dfPPI
Dysfunctional Protein-Protein Interactome (dfPPI) is significantly advancing our understanding of disease by mapping stress-induced changes in protein networks, critical to phenotype and disease manifestation. #SystemsBiology #dfPPI (2)
Earlier this month Chiosis Lab postdoc Souparna presented at #cshlnetworks on the #dfPPI platform, a powerful #Chemoproteomics tool to decode stressor-induced #ProteinNetworks dysfunctions in #CancerResearch & #NeurodegenerativeDiseases 🧠👨💻
🎊Congrats on your talk Souparna! @cshlmeetings.bsky.social
