Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis TRPV2 is the least studied member of the vanilloid TRP subfamily despite its emerging relevance in cancer metastasis, pain, and inflammation. Although several small-molecule TRPV2 modulators have been...

very happy to finally share a key chapter of my PhD/postdoc journey in the GBernardes Lab 🎉

If you're interested in electrophilic natural products, TRP channels, or chemoproteomics, you may enjoy reading it 🫑 🌶️ pubs.acs.org/doi/10.1021/... #TRP #TRPV2 #chemoproteomics

#ABPP2027 will be happening in Leiden on June 2nd to 4th, 2027.

I am excited to be part of the organization together with an amazing team.

Sign up for our mailing list here: www.universiteitleiden.nl/en/science/l...

#ABPP #ChemoProteomics #ChemPro #ProteoProbes #ChemSky #ChemBio #DrugDiscovery

#ABPP #ChemoProteomics #ChemPro #ProteoProbes #ChemSky #ChemBio #DrugDiscovery

Join us for lunch at #USHUPO2026 today!

Lindsay Pino (@TalusBio) and Tim Heymann (Mann Lab) show how the #ZenoTOF8600 system powers deep discovery, targeted verification, single‑cell to global #proteomics, and #chemoproteomics with #Skyline: sciex.li/xoemx7

🕛 12:30–13:30 | 📍 Grand Ballroom AB

@lindsaykpino.com shares how chromatogram‑based #chemoproteomics using the #ZenoTOF8600 and #Skyline enables residue‑level detection of covalent binding events with depth, robustness, and throughput.

🗓️ Feb 23 | ⏰ 12:30–13:30
📍 Grand Ballroom AB, Hyatt Regency St. Louis
sciex.li/xoemx7
#USHUPO2026

Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling Profiling the reactivity of the proteome with amino-acid level resolution requires the identification and quantification of reacted peptides in the presence of abundant unmodified peptides. Affinity-b...

The group of Jacob Geri published a method for residue-specific #chemoproteomics without the need for an enrichment step. To achieve this, they developed reagents that shift the ion mobility of modified peptides for gas phase separation. (2/12)
pubs.acs.org/doi/full/10....

#Chemoproteomics

Take-home: ABPP can bridge genotype→phenotype gaps and complement genomic surveillance, a practical way to anticipate cross-resistance and de-risk insecticide rollout/rotation strategies. #malaria #vectorcontrol #chemoproteomics 

Aspasia Dimitriadou explaining competitive chemoproteomics assay.

Today took place the 12th Young Scientists Forum of the Hellenic Society of Biochemistry and Molecular Biology as a pre-event of the #EEBMB2025 conference. As evidenced by Aspasia Dimitriadou’s presentation, #chemoproteomics is putting down roots in Athens. And I won’t hide my pride.

Very happy that @marnixroseboom.bsky.social represented our group of the @led3hub.bsky.social with a very well-attended talk at #NWOCHAINS. He reported on his #PhD work on developing #ChemoProteomics technologies to study #CovalentInhibitor target engagement at arginines.

#ChemSky #ChemBio #ProudPI

We are getting our slides and posters ready! In a few days, NKUA Proteomics Core Facility goes EEBMB2025. We have from sponge proteomics to chemoproteomics for you, including multiple myeloma proteomics as well as murine multiomics.
#Chembio #Proteomics #chemoproteomics

Great to see our Nature Chemistry paper out in its final published and printed form.

If you want to check it out, you can find it here: www.nature.com/articles/s41...

#ChemSky #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro

This project started 5 years ago. It led us to add isotope-labeling support to #FragPipe/#IonQuant. Since then, the tools have grown so much and are now widely used in #Chemoproteomics.

Huge thanks to everyone, and special thanks to @stephanhacker2.bsky.social and @pzanon.bsky.social

Big pharma seduced by transcription factors again. What has changed? - Nature Biotechnology Long considered undruggable, transcription factors have finally become fair game for a clutch of innovative biotechs who are combining biological insights with innovative chemistry to bring into play ...

Are #TranscriptionFactors no longer "undruggable"? Recent innovations in small molecule chemistry, peptide design, #chemoproteomics, #structuralbiology make modulating #TranscriptionFactor activity possible ➡️
www.nature.com/articles/s41...

If you have an interest in HDAC inhibitors, do not hesitate to reach out to us to have a run through of our chemoprotemics work helped by poster P066 and P018 at #ChemBioParis2025. #ChemBio #chemoproteomics

FEBS Press The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentat...

Nice to be mentioned in the recently published account of the conference!
Kudos to @sevlechner.bsky.social
#EV #chemoproteomics

febs.onlinelibrary.wiley.com/doi/full/10....

#ChemBio #chemoproteomics @kusterlab.bsky.social

PhD Candidate in Chemical Biology and Immuno-metabolism The Faculty of Science Leiden, the Leiden Institute of Chemistry and Leiden Institute of Biology are looking for a PhD candidate to pursue research on the development of drugs modulating immunometabol...

If you are interested in #chemoproteomics, #immunology and #DrugDiscovery, here is your chance to work as a #PhD candidate with an amazing mentor (@mads-chem.bsky.social) within the @led3hub.bsky.social.

www.universiteitleiden.nl/en/vacancies...

#Chemsky #ChemBio @leidenscience.bsky.social

Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling Profiling the reactivity of the proteome with amino-acid level resolution requires the identification and quantification of reacted peptides in the presence of abundant unmodified peptides. Affinity-b...

An inspiring paper by the group of Jacob Geri in Analytical Chemistry. They present a method for residue-specific #chemoproteomics without the need for an enrichment step. To achieve this, they developed reagents that shift the ion mobility for gas phase separation. pubs.acs.org/doi/full/10....

Join @lindsaykpino.com, me, and our amazing panelists for the #ASMS2025 #Chemoproteomics workshop on Monday!

#ChemBio #Chemoproteomics

Chemical proteomics for a comprehensive understanding of functional activity and the interactome Traditional mass spectrometry (MS)-based proteomics aims to detect and measure protein expression on a global scale and elucidate the link between protein function and phenotypic characteristics. Alth...

It is Gold Open Access paper, so everyone can check it out. It is quite extensive work so I want to thanks to Kostia for his great contributions.

doi.org/10.1039/D5CS...

#chemoproteomics #targetID #PPI #Interactome #chemicalpharmacology

Very excited that Ed Tate will visit us for a @led3hub.bsky.social Lecture on May 22nd and talk about cutting-edge #ChemBio and #chemoproteomics research in the field of #DrugDiscovery. If you are interested, feel free to come by!

#ChemSky

Had a great time today discussing the power of #chemoproteomics to help develop #drugs with novel mechanisms of action today for @flgenomics.bsky.social webinar series. Great to see the #chemistry, #AI #proteomics, and #genomics communities coming together to drive change drug development!

EU-OPENSCREEN Presents New Service Platform in Chemoproteomics and Spatial MS-Based Omics at HDDC 2025 in Berlin EU-OPENSCREEN's three new partner sites presented their advanced capabilities in chemoproteomics and spatial mass spectrometry (MS)-based omics in a dedicated session at this year's Helmholtz Drug Dis...

Did you know that EU-OPENSCREEN now supports collaborations in #chemoproteomics and spatial mass spec-based omics?

This week, our new partners at @ki.se @tum.de and CeMOS Mannheim gave a fantastic workshop this week about their new offers for EU-OS.

Learn more: www.eu-openscreen.eu/newsroom/eu-...

Another day at #AACR25! If you're interested in #ChemoProteomics or #Immunopeptidomics, make sure not to miss our two posters.

Visit Booth #4045 to explore how #proteomics can advance your #CancerResearch and create your own #MadeOfProteins T-shirt!

Learn more: biognosys.com/conferences/...

🎯#dfPPI employs protein complexes that form under stress conditions as biological baits, capturing disease-specific changes in protein interactions within native cellular environment. This improves relevance & accuracy of the findings in biological contexts. #Chemoproteomics (3)

We had a fantastic time at the "Pioneering Mass Spectrometry and #Chemoproteomics" symposium!

We loved the chance to dive into our LiP-MS and P2 #proteomics CRO services and method transfer options.

Learn more about P2: biognosys.com/services/pla...

#DrugDiscovery #DrugDevelopment #Plasma

#FocusOnCovalentDrugs was a great meeting with talks covering diverse aspects of targeted covalent inhibitor discovery ranging from warhead development and #chemoproteomics to very advanced PK/PD topics. Thank you so much to the organizers for inviting me and to everyone for the fruitful discussions

Amazing talk by Sebastian Essig at #FocusOnCovalentDrugs. He talked about covalent drug discovery with a focus on characterizing novel warheads. Great insights into library design, reactivity profiling and #chemoproteomics for global analysis of selectivity.