Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis TRPV2 is the least studied member of the vanilloid TRP subfamily despite its emerging relevance in cancer metastasis, pain, and inflammation. Although several small-molecule TRPV2 modulators have been...

very happy to finally share a key chapter of my PhD/postdoc journey in the GBernardes Lab 🎉

If you're interested in electrophilic natural products, TRP channels, or chemoproteomics, you may enjoy reading it 🫑 🌶️ pubs.acs.org/doi/10.1021/... #TRP #TRPV2 #chemoproteomics

Structural insights into TRPV2 modulation by probenecid Nature Structural & Molecular Biology - The authors reveal that probenecid, an FDA-approved drug, uniquely modulates TRPV2 through an intracellular pocket. Probenecid drives the channel into an...

Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid"
#cryoEM #TRPV2 #TRPchannels

www.nature.com/articles/s41...

Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance Transient receptor potential cation channels have been implicated in the regulation of cardiovascular function, but only recently has our laboratory described the vanilloid-2 subtype (TRPV2) in the ca...

Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance #TRPV2

pmc.ncbi.nlm.nih.gov/articles/PMC...

#TRPV2 "is necessary for normal cardiac function and that there is increased contractility in response to agonism of TRPV2 with probenecid."