Scanning DIA on the ZenoTOF 8600 system enables ultra-sensitive and quantitative proteomics from single cells to post-translational modifications in a compact platform Mass spectrometry-based proteomics increasingly demands platforms that combine quantitative rigor with the discovery capabilities of accurate mass systems. Here we present the ZenoTOF 8600 system, a compact mass spectrometry system that integrates enhanced ion capture and transmission optics with an optical detection system, Zeno trap-enhanced MS/MS, electron-activated dissociation, and scanning quadrupole data-independent acquisition (ZT Scan DIA). We show that ZT Scan DIA outperforms conventional variable-window DIA (Zeno SWATH DIA) in both identifications and quantitative reproducibility, and demonstrate the platform’s versatility across proteomics applications: thousands of protein groups from bulk samples at up to 500 samples per day, single-cell proteomics yielding up to 4,700 proteins, accurate ratio recovery in mixed-species quantitative benchmarks, low-attomole targeted quantitation, and detection of disease-relevant phosphorylation in a Parkinson’s disease cellular model using complementary CID and EAD fragmentation. The instrument’s compact footprint makes it attractive for settings where both analytical breadth and operational robustness are required.

ZT Scan DIA > conventional DIA ✅
More IDs.
<4% protein CVs.
Better reproducibility.
Depth and precision—at the same time.

Check out the latest preprint from the Mann lab to learn more: buff.ly/tvralVM

#ZTScanDIA #ZenoTOF8600 #Proteomics

Scanning DIA on the ZenoTOF 8600 system enables ultra-sensitive and quantitative proteomics from single cells to post-translational modifications in a compact platform Mass spectrometry-based proteomics increasingly demands platforms that combine quantitative rigor with the discovery capabilities of accurate mass systems. Here we present the ZenoTOF 8600 system, a compact mass spectrometry system that integrates enhanced ion capture and transmission optics with an optical detection system, Zeno trap-enhanced MS/MS, electron-activated dissociation, and scanning quadrupole data-independent acquisition (ZT Scan DIA). We show that ZT Scan DIA outperforms conventional variable-window DIA (Zeno SWATH DIA) in both identifications and quantitative reproducibility, and demonstrate the platform’s versatility across proteomics applications: thousands of protein groups from bulk samples at up to 500 samples per day, single-cell proteomics yielding up to 4,700 proteins, accurate ratio recovery in mixed-species quantitative benchmarks, low-attomole targeted quantitation, and detection of disease-relevant phosphorylation in a Parkinson’s disease cellular model using complementary CID and EAD fragmentation. The instrument’s compact footprint makes it attractive for settings where both analytical breadth and operational robustness are required.

One platform.
10× sensitivity.
Single cells → PTMs → targeted assays.

In this preprint by the Mann lab, explore how the #ZenoTOF8600 system is redefining what a single mass spec system can achieve, from deep discovery #proteomics to targeted verification and validation studies:

Join us for lunch at #USHUPO2026 today!

Lindsay Pino (@TalusBio) and Tim Heymann (Mann Lab) show how the #ZenoTOF8600 system powers deep discovery, targeted verification, single‑cell to global #proteomics, and #chemoproteomics with #Skyline: sciex.li/xoemx7

🕛 12:30–13:30 | 📍 Grand Ballroom AB

Tim Heymann (Mann Lab) shows how the #ZenoTOF8600 system powers deep discovery to targeted verification, plus its compatibility with Evosep Eno, IonOpticks Aurora XS, and PEAKS for end‑to‑end proteomics: sciex.li/xoemx7
🗓️ Monday | ⏰ 12:30–13:30 | 📍 Grand Ballroom AB
#USHUPO2026 #SingleCellProteomics

Tim Heymann shows how the #ZenoTOF8600 system powers deep discovery to targeted verification, plus its compatibility with Evosep Eno, IonOpticks Aurora XS, and PEAKS for end‑to‑end #proteomics.
sciex.li/xoemx7

🗓️ Monday | ⏰ 12:30–13:30 | 📍 Grand Ballroom AB
#USHUPO2026 #SingleCellProteomics

@lindsaykpino.com shares how chromatogram‑based #chemoproteomics using the #ZenoTOF8600 and #Skyline enables residue‑level detection of covalent binding events with depth, robustness, and throughput.

🗓️ Feb 23 | ⏰ 12:30–13:30
📍 Grand Ballroom AB, Hyatt Regency St. Louis
sciex.li/xoemx7
#USHUPO2026

Ready to push #proteomic discovery further?
Visit us at Booth 19 during #USHUPO2026 to explore our latest platforms, applications, and data‑analysis innovations. Meet the team and see how our solutions accelerate high‑impact research.

Register for our lunch seminar: sciex.li/xoemx7

#ZenoTOF8600

🍽️ Join us for lunch at #USHUPO2026!
SCIEX is hosting a sponsored seminar featuring advances in high‑resolution accurate‑mass #proteomics and real‑world insights from leading experts using the ZenoTOF 8600 system.
🗓️ Feb 23 | ⏰ 12:30–13:30
📍 Grand Ballroom AB

🎟️ Register: sciex.li/xoemx7

#ZenoTOF8600

We're heading to US HUPO 2026!

Visit Booth 19 to explore our latest innovations for #proteomics. Whether you're driving translational research or biomarker discovery, we're ready to support your next breakthrough. 💪⚡

📍 St. Louis | Booth 19

#USHUPO2026 #USHUPO #ZenoTOF8600

Be the first to experience our brand-new system, designed to accelerate workflows, unlock deeper insights, and push the boundaries of innovation. 👀

Come talk to our team at #Danaher booth 2108 and see it live! 👉 sciex.li/d7mgw4

#ZenoTOF8600 #EchoMSPlus #SLAS2026

Demand Proof - A sceptics dream product launch "Turning scepticism into proof: SCIEX's innovative ZenoTOF 8600 launch sparks industry debate and leads, #massspectrometry #ZenoTOF8600"

Turning skepticism into proof = award-winning strategy.

Our ZenoTOF 8600 launch earned Gold at The Drum Awards for B2B Product Launch!

Read how we flipped the script: www.thedrum.com/awards-case-...

#MassSpectrometry #ZenoTOF8600 #Innovation #DanaherNews #TheDrumAwards

Mass Spec Brings Multiomics Into Sharper Focus Improvements in sensitivity, specificity, and accurate quantitation allow researchers to glean valuable information from hundreds of samples in record time.

Multiomics demands more from mass spec.

The ZenoTOF 8600 system is helping researchers expand coverage across proteomics and metabolomics with faster scans and greater sensitivity.

🔗 buff.ly/JK3LE65

#MassSpec #Multiomics #Proteomics #Metabolomics #SCIEX #ZenoTOF8600

Veloxity Labs Acquires SCIEX Accurate Mass Spectrometer, the ZenoTOF 8600 System, to Accelerate Peptide and Complex Bioanalysis The first bioanalytical CRO in the United States to bring the ZenoTOF 8600 system online; expands capacity and adds selectivity/sensitivity headroom for GLP-1 receptor agonists and broader peptide…

#DidYouHear? US-based CRO Veloxity Labs continues to expand its bioanalytical capabilities with the ZenoTOF 8600 system 👀

This marks a meaningful step forward in complex bioanalysis.

🔗 www.biospace.com/press-releas...

#MassSpec #Bioanalysis #Peptides #Proteomics #SCIEX #ZenoTOF8600

SCIEX ZenoTOF 8600 system acquired by Veloxity Labs Veloxity Labs acquires the SCIEX ZenoTOF 8600 system to accelerate peptide and complex bioanalysis.

Veloxity Labs is the first U.S. bioanalytical CRO to adopt the #ZenoTOF8600 system! The platform adds high-resolution selectivity and sensitivity to peptide workflows, supporting GLP-1 receptor agonists and complex matrices.

We're proud to support this expansion in regulated #bioanalysis.
#MassSpec

Hear from industry experts and members of #TeamSCIEX why the newest innovation in mass spectrometry is just so exciting. 👇👇👇

#SkepticsWelcome #ZenoTOF8600 #TeamMassSpec

Demand proof.

#SkepticsWelcome #ZenoRevolution #ZenoTOF8600

#TeamSCIEX Singapore welcomed our new president Chris Hagen last month! His visit energized the team and marked the launch of the #ZenoTOF8600. Great conversations, strong leadership, and innovation in action. Exciting times ahead!
#SCIEXSingapore #LeadershipVisit #MassSpec

How High-Resolution Mass Spectrometry Is Powering Omics Innovation With Tatjana Talamantes At ASMS 2025, the Technology Networks team caught up with Tatjana Talamantes, Senior Product Manager, High Resolution Accurate Mass at SCIEX, to discuss the rapid evolution of high-resolution mass…

🎥 Tech Networks caught up with Tatjana Talamantes, who breaks down how high-res mass spec is leveling up sensitivity, ID confidence & unlocking new omics apps. 🚀
Watch the full chat to see how smart design + flexible tools are changing the game!
#ZenoTOF8600 #MassSpec #Omics #SkepticsWelcome

🎉 That’s a wrap on #SCIEXperience Malaysia! A week of science and connection, incl seminars at Sunway University & University of Malaya spotlighting mass spec in omics and #PFAS testing. Participants also got a sneak peek at the #ZenoTOF8600 system, our next-gen high-resolution mass spectrometer!

Advancing Proteomics Workflows: Innovations and Insights With Chris Lock At ASMS 2025, the Technology Networks team spoke with Chris Lock from SCIEX to discuss how improvements in proteomics technology, including in sensitivity and identification, are enabling researchers…

🎤 At #ASMS2025, our own Chris Lock shared with Technology Networks how proteomics tech is getting sharper—more sensitivity, easier ID, and smoother workflows thanks to smart software upgrades. 💻🔬
Catch the full video now! 👇
#MassSpec #Proteomics #ZenoTOF8600

大阪・東京で開催されるSCIEX LC-MSフォーラム2025のご案内 2025年9月に大阪と東京で開催されるSCIEX LC-MSフォーラムの詳細情報をお届けします。最新の技術が集結する貴重な機会です。

大阪・東京で開催されるSCIEX LC-MSフォーラム2025のご案内 #大阪府 #SCIEX #ZenoTOF8600 #LC-MSフォーラム

2025年9月に大阪と東京で開催されるSCIEX LC-MSフォーラムの詳細情報をお届けします。最新の技術が集結する貴重な機会です。

SCIEX sets a new standard in accurate mass quantitation with the ZenoTOF 8600 system and new software collaborations With the launch of the ZenoTOF 8600 system and new software partnerships, SCIEX advances accurate mass quantitation by delivering unprecedented sensitivity, speed, and data clarity across all omics…

“This year’s launches will enable us to see exciting impact across #OMICS research. We are motivated by what our customers tell us, that they can foresee real-world outcomes as a result of the new data generated and the insights interpreted."

#DanaherNews #ZenoTOF8600 #SkepticsWelcome

Are you looking forward to attending #EuPA2025 in beautiful Saint-Malo? Get ready for an enriching experience in extraordinary #proteomics!

🗓️ Mark your calendar for the SCIEX lunch symposium, taking place on Wednesday, June 18!

🔗 Full show agenda 👉 bit.ly/3HcA6Hw

#SkepticsWelcome #ZenoTOF8600

Thanks to StreetInsider.com for helping us spread the news about our latest innovation, the #ZenoTOF8600 system, launched at #ASMS2025 last week!!! 🥳🎉

🔗: www.streetinsider.com/Business+Wir...

#DanaherNews

#InTheNews: SCIEX Sets a New Standard in Accurate Mass Quantitation With the ZenoTOF 8600 System and New Software Collaborations 👏 🎉

🔍 Read the article 👉 buff.ly/tyywuRu

#DanaherNews #ZenoTOF8600 #SkepticsWelcome

Thank you to everyone who joined us for our final showing of #ProofPoint last night! As always, it was a pleasure to host everyone in our Hospitality Suite, and we can't wait to do it all over again next year! #ASMS2026

In the meantime, check out our new #ZenoTOF8600 system: sciex.li/7bhhp6

We couldn't do it without our amazing team, and of course our customers! 👏

#ThankYou #ZenoTOF8600 #ASMS2025

Be skeptical.

That's part of what makes you a #scientist 🧑‍🔬 🧪 🔬

Download the technical data from our new ZenoTOF 8600 system and see for yourself 👉 sciex.li/docvdc

#ASMS2025 #ZenoTOF8600 #SkepticsWelcome

"Using EAD on the #ZenoTOF8600, customers studying the metabolome can now fully characterize circulating metabolites that were previously barely detectable." - Jose Castro Perez, VP Product Management

Watch the full launch: sciex.li/cz0ypi

#ASMS2025 #SkepticsWelcome

Sciex sets new standard in accurate mass quantitation with ZenoTOF 8600 System Sciex sets new standard in accurate mass quantitation with ZenoTOF 8600 System

Thank you to BioSpectrum India for helping us to spread the #news about one of our most exciting launches. But you don't have to take our word for it... 😜

Learn more: www.biospectrumindia.com/news/16/2619...

#AccurateMass #ZenoTOF8600 #SkepticsWelcome #DanaherNews