Had an excellent time at #NWOCHAINS 2025. It's always nice to see the huge diversity in chemistry research in the Netherlands! I am lucky to be part of it.
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#NWOCHAINS comes to an end with the closing ceremony led by Ioana Ilie (@biosim-lab.bsky.social)!
I had two days of exciting science and learned a lot. Thank you to everyone, who was involved in organizing and who contributed to the program. Congratulations to all winners of the poster prizes!
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Interesting talk by Florian Ort from the group of Floris Rutjes at #NWOCHAINS. He talked about the use of #mechanochemistry for solvent-free, racemization-free #peptide #ligation. Exciting applications for #NativeChemicalLigation of insoluble peptides.
#ChemSky #ChemBio #GreenChemistry
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Very happy that @marnixroseboom.bsky.social represented our group of the @led3hub.bsky.social with a very well-attended talk at #NWOCHAINS. He reported on his #PhD work on developing #ChemoProteomics technologies to study #CovalentInhibitor target engagement at arginines.
#ChemSky #ChemBio #ProudPI
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Interesting talk by Foteini Skoulikopoulou of the group of @armstrongchembio.bsky.social of the @led3hub.bsky.social at #NWOCHAINS. She talked about her research into the synthesis of stable 9-O-acetylated sialic acid mimics with potential applications as #antivirals.
#glycotime #ChemSky #ChemBio
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Interesting talk by Friedrich Förster at #NWOCHAINS. He talked about his group's exciting research into visualizing protein biogenesis at the ER membrane using cryo-electron microscopy and cryo-electron tomography.
www.nature.com/articles/s41...
#cryoEM #proteins #structure
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Another great session of #PosterPitches at #NWOCHAINS. We learned about a huge diversity of topics including #SupramoecularAssemblies, #biomarker #sensing, #Ion-selective #membranes, radical #polymerization and #MassSpectrometry.
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@seanmckenna.bsky.social represented the group of @sebastianpomplun.bsky.social and the @led3hub.bsky.social with an exciting talk at #NWOCHAINS. He talked about using a combination of in silico screening and semi-automated synthesis to accelerate #DrugDiscovery.
#ChemSky #ChemBio
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Excited that Yorick van Aalst represented our group of the @led3hub.bsky.social with a talk at #NWOCHAINS. He talked about mining #AlphaFold structures of the entire proteome for pockets and using this information to prioritize hits from #Chemoproteomic screens.
#ChemSky #ChemBio #ProudPI
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Exciting talk by Charalampos Ntallis from the group of Markus Weingarth at #NWOCHAINS. He talked about his exciting research into using solid-state #NMR to understand the interaction between the last resort #antibiotic #polymyxin and #LPS on the molecular level.
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Insightful talk by Bob van Puffelen from the groups of Jeroen Codee and Dima Filippov @leidenadpr.bsky.social of the @led3hub.bsky.social at #NWOCHAINS. He talked about a glycan modification of the bacterial flagellum and how they use synthetic tools to study its biosynthesis.
#ChemSky #ChemBio
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Great talk by Cristina Lopez Gallego from the group of Marcellus Ubbink of our @led3hub.bsky.social of @leidenscience.bsky.social at #NWOCHAINS. She talked about the study of second sphere residues and their effect on the structure, dynamics and function of beta-lactamases.
#Biochemistry #Evolution
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Insightful talk by Anthe Janssen at #NWOCHAINS. He talked about his research with Dompé in the framework of #ChemistryNL on using #docking and #MachineLearning-assisted re-scoring to better predict compound binding affinity to #kinases.
pubs.acs.org/doi/10.1021/...
#ChemSky #ChemBio #DrugDiscovery
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Amazing talk by Sander Woutersen at #NWOCHAINS. He gave an entertaining talk on his Ig Nobel Prize winning research on using (drunk) worms as a model for active polymers to better understand their exciting properties.
iop.uva.nl/content/news...
www.science.org/doi/10.1126/...
#Chemistry #Polymers
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Great talk by Bianca van Tol at #NWOCHAINS. She talked about the development of neutron-encoded ubiquitins and diubiquitins to study the linkage selectivity of E2 enzymes, E3 ligases and deubiquitinating enzymes.
www.nature.com/articles/s41...
#ChemSky #ChemBio #Ubiquitin
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Great talk by Floor Stevens from the group of @mvdstelt.bsky.social of our @led3hub.bsky.social at #NWOCHAINS. She talked about her research into "Discovery of a novel metabolic pathway for N-acylethanolamines by cytosolic glucosylceramidase 2".
#Chemistry #ChemBio #LipidTime #Glycotime
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Insightful talk by Dieuwertje Streefkerk at #NWOCHAINS. She talked about their synthetic work on stereochemically defined sulfur(VI) electrophiles and their use as #CovalentInhibitors on the example of chymotrypsin inhibition.
onlinelibrary.wiley.com/doi/full/10....
#ChemSky #ChemBio #Electrophiles
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Exciting talk by Kevin Neumann (@neumannlab.bsky.social) at #NWOCHAINS. He talked about the tetrazine- and triazine-thiol exchange reactions for #bioconjugation and #peptide cyclization. He also discussed their potential application for #CovalentInhibitors.
onlinelibrary.wiley.com/doi/full/10....
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Great talk by Marta Artola at #NWOCHAINS. She talked about the use of modified sugars as inhibitors and molecular #chaperones in #DrugDiscovery. Great insights into the use of cyclic sulfamates and sulfamidates as reactive groups for #CovalentInhibitors
pubs.acs.org/doi/10.1021/...
#ChemSky #ChemBio
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"Novel Covalent Inhibitors and Where to Find Them"
I was very excited that Madeline Kavanagh, Marc Baggelaar, Rita Petracca and I were awarded a focus session at #NWOCHAINS. We had an amazing program with talks by Marta Artola, Kevin Neumann and Dieuwertje Streefkerkand a panel discussion. (1/3)
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The poster pitches at #NWOCHAINS were an absolute firework of great #science on #antivirals, #organocatalysis, #MolecularMotors, #EnzymeEngineering, #photocontrol, #odor, #bacteria, #recycling, #batteries, #QuantumDots, #vitrimers, #BoneRegeneration, native #MassSpectrometry and #biomaterials.
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Our postdoc Valeria Poggetti @valeriapoggetti.bsky.social presented her work on Nucleophilic Catalysis in Thiophenol-Based Designer Enzymes at #NWOChains
@stratinghinst.bsky.social @rug.nl
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Interesting talk by Tobias Erb at #NWOCHAINS. He talked about building complex, artificial enzyme networks that can fix CO2 and produce high value molecules driven e.g. by light or electricity as energy source.
www.science.org/doi/10.1126/...
www.cell.com/joule/fullte...
#ChemSky #ChemBio #Energy
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The scientific program of #NWOCHAINS starts with the opening words by Sandra de Keijzer, head of NWO Chemistry and Physics, and Ioana Ilie (@biosim-lab.bsky.social), chair of the programme committee of CHAINS.
#ChemSky #ChemBio #Conferencing
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Two days of connecting the Dutch Academic Community are coming up at #NWOCHAINS.
Yesterday, we already had the New PI meeting and the PI meeting with a lot of great content. (1/8)
#ECR #PI #Chemistry #ChemBio #Connections #NewPI
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Had some fun at #nwochains this year. 🌞 Presenting a poster and discussing with researchers in chemistry definitely offered some new perspectives. It was also great to catch up with some friends from the PhD.
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Thrilled to present Alphabridge in the Computational Chemistry session at #NWOChains! We aim to facilitate researchers to analyze interacting interfaces in predicted biomolecular structures. Honored to share insights with top chemists in the Netherlands. 🚀🔬 Preprint: www.biorxiv.org/content/10.1...
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