Microplastic abundance in placental chorionic villi detected by pyrolysis-gas chromatography/mass spectrometry in cases of spontaneous miscarriage during early pregnancy #eBioMedicine www.thelancet.com/journals/ebi...

Discovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysis These candidate biomarkers add to our understanding of PD pathophysiology and the relationship between PD and DLB. They provide further research directions toward disease-modifying therapies.

Discovery and validation of biomarkers for Parkinson’s disease from human cerebrospinal fluid using mass spectrometry-based proteomics analysis #EBioMedicine #MassSpec www.thelancet.com/journals/ebi...

Serum metabolic fingerprints encode functional biomarkers for ovarian cancer diagnosis: a large-scale cohort study Our study established a reliable serum metabolic biomarker panel for OC diagnosis with potential clinical translations. The NELDI-MS based approach offers advantages of fast analytical speed (∼30 s/sa...

Serum metabolic fingerprints encode functional biomarkers for ovarian cancer diagnosis: a large-scale cohort study #eBioMedicine #MassSpec www.thelancet.com/journals/ebi...

Single-cell multi-omics profiling uncovers the immune heterogeneity in HIV-infected immunological non-responders Our study provides new insights into the pathogenic mechanisms behind immune recovery failure in INRs, suggesting that IFN signalling might be involved in the development of CD4+ T cell exhaustion. Th...

🧬🔬 New study reveals immune heterogeneity in HIV non-responders! Key genes and pathways linked to CD4+ T cell exhaustion and interferon signalling identified. 📊🦠 #HIV #Immunology #Research #eBioMedicine #openaccess

Blood N-glycomics reveals individuals at risk for cognitive decline and Alzheimer’s disease Reduced blood N-glycan levels predict cognitive decline independent of amyloid or tau status. Blood N-glycome profiling could be used to identify individuals at risk for AD dementia.

Blood N-glycomics reveals individuals at risk for cognitive decline and Alzheimer's disease #EBioMedicine #MassSpec www.thelancet.com/journals/ebi...

Which experimental factors govern successful animal-to-human translation in multiple sclerosis drug development? A systematic review and meta-analysis Our findings emphasize the complexity in carrying drugs from animals to clinical practice. Specific challenges include limited experimental methods in animal research and a disconnect between preclini...

In #eBioMedicine, Berg et al. (including @mseq.bsky.social ) of the University of Zurich & NINDS aimed to identify factors in animal studies of #MultipleSclerosis drugs that predicted their successful translation.
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Mortality-associated plasma proteome dynamics in a prospective multicentre sepsis cohort This study describes temporal changes in the plasma proteome associated with mortality in sepsis. These findings offer new insights into sepsis pathophysiology, emphasizing the innate immune system as an underexplored network, and may inform the development of targeted therapeutic strategies.

Mortality-associated plasma proteome dynamics in a prospective multicentre sepsis cohort #eBioMedicine #MassSpec www.thelancet.com/journals/ebi...

Microbiome and metabolomics reveal the effect of gut microbiota on liver regeneration of fatty liver disease These data demonstrated the interplay between the gut microbiome, liver metabolomics, and liver regeneration in mice with MAFLD. A. muciniphila has the potential to serve as a clinical intervention agent to accelerate postoperative recovery in MAFLD.

Microbiome and metabolomics reveal the effect of gut microbiota on liver regeneration of fatty liver disease #eBioMedicine #MassSpec www.thelancet.com/journals/ebi...

COVID-19 linked to rise in autoimmune lung disease, study finds A study in eBioMedicine identifies shared immunopathology between SARS-CoV-2 infection and MDA5 autoimmunity, highlighting a surge in MDA5+ cases and interstitial lung disease during the COVID-19 pand...

COVID-19 linked to rise in autoimmune lung disease, study finds 🦠🫁🔬 www.news-medical.net/news/2024051... #Autoimmunity #COVID19 #LungDisease #Immunology #MDA5 #eBioMedicine #Research #PublicHealth #Pandemic