✋🏼☎️Please comment on your experience with Fibrillary GN.
📋How were the outcomes?
#fibrillaryGN #ECNeph @DrSumanBehera @myadla @arkanalabs @ISNkidneycare
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#fibrillaryGN
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✋🏼☎️Please comment on your experience with Fibrillary GN.
📋How were the outcomes?
#fibrillaryGN #ECNeph @DrSumanBehera @myadla @arkanalabs @ISNkidneycare
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🔬EM -Random fibrillar deposits in mesangium & glom capillary walls
🧶Fibrils in FGN -16-24nm
🧶Amyloidosis -10 nm
🥢🥢Fibrils in FGN - randomly arranged,
‖‖‖‖ Microtubules in immunotactoid glom-pathy -parallel bundles
#fibrillaryGN #ECNeph @DrSumanBehera @myadla @ISNkidneycare
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🔬EM -Random fibrillar deposits in mesangium & glom capillary walls
🧶Fibrils in FGN -16-24nm
🧶Amyloidosis -10 nm
🥢🥢Fibrils in FGN - randomly arranged,
‖‖‖‖ Microtubules in immunotactoid glom-pathy -parallel bundles
#fibrillaryGN #ECNeph @DrSumanBehera @myadla @ISNkidneycare
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🎭PARAFFIN IF may reveal "masked" polytypic deposits when monotypic deposits are seen on standard frozen section IF 🎭
🎯Avoids misdiagnosis with monoclonality.
#fibrillaryGN #ECNeph #paraffinIF #immunofluorescence @DrSumanBehera @myadla @ISNkidneycare
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🎭PARAFFIN IF may reveal "masked" polytypic deposits when monotypic deposits are seen on standard frozen section IF 🎭
🎯Avoids misdiagnosis with monoclonality.
#fibrillaryGN #ECNeph #paraffinIF #immunofluorescence @DrSumanBehera @myadla @ISNkidneycare
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🧩 IF - IgG, C3, Polyclonal (both 𝜅 & ƛ) light chains.
☀️Predominant deposition of IgG subclass, particularly IgG4, sometimes IgG1.
💢IgA, IgM & C1q deposition may be seen
#fibrillaryGN #ECNeph @DrSumanBehera @myadla @ISNkidneycare
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🧩 IF - IgG, C3, Polyclonal (both 𝜅 & ƛ) light chains.
☀️Predominant deposition of IgG subclass, particularly IgG4, sometimes IgG1.
💢IgA, IgM & C1q deposition may be seen
#fibrillaryGN #ECNeph @DrSumanBehera @myadla @ISNkidneycare
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🔬#BIOPSY findings:
💡Light Microscopy -Mesangioproliferative/sclerosing GN 71%
Membranoproliferative GN 15%
#fibrillaryGN #ECNeph @DrSumanBehera @myadla @ISNkidneycare
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🔬#BIOPSY findings:
💡Light Microscopy -Mesangioproliferative/sclerosing GN 71%
Membranoproliferative GN 15%
#fibrillaryGN #ECNeph @DrSumanBehera @myadla @ISNkidneycare
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🌀#Amyloidosis (AL) vs #FibrillaryGN vs #Immunotactoid glomerulopathy
⚠️How do we differentiate?
🦓🦒Distinct features.🤖
#ECNeph @DrSumanBehera @myadla @agnesfogo @ISNkidneycare
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🌀#Amyloidosis (AL) vs #FibrillaryGN vs #Immunotactoid glomerulopathy
⚠️How do we differentiate?
🦓🦒Distinct features.🤖
#ECNeph @DrSumanBehera @myadla @agnesfogo @ISNkidneycare
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