Incredible moments on and off the stage at Day 2 of #Glyco27

What moments are you capturing?

#glycobiology #glycomics #glycoconjugates

Automated Synthesis of C1-Functionalized Oligosaccharides Automated glycan assembly (AGA) streamlines the synthesis of complex oligosaccharides. The reducing end of the oligosaccharide serves as an attachment site to the polymer support to liberate a free reducing end or an aminopentanol for ready conjugation to carrier proteins or surfaces. The facile installation of different aglycons on oligosaccharides has not been possible via AGA until now. Here, we describe a latent-active approach enabled by a traceless photolabile linker that allows for bidirectional AGA and ready introduction of various aglycons. Oligosaccharide thioglycosides, peptidoglycans, prototypical saponins, and click-chemistry-based conjugates are synthesized to illustrate the versatility of the method.

Start the year with a hot-off-the-press paper!

Most #glycans exist as #glycoconjugates - our scientists describe access to #saponins and many other useful #glycotime molecules by automated glycan assembly.

#chemsky

pubs.acs.org/doi/full/10....