Mindaugas Snipas et al. developed a #mathematicalmodel of voltage gating of unapposed connexin #hemichannels 💻 ⚙️

Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Tonabersat suppresses priming/activation of the NOD-like receptor protein-3 (NLRP3) inflammasome and decreases renal tubular epithelial-to-macrophage crosstalk in a model of diabetic kidney disease - ... Background Accompanied by activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, aberrant connexin 43 (Cx43) hemichannel-mediated ATP release is situated upstream of inflammasome assembly...

Tonabersat suppresses priming/activation of the NOD-like receptor protein-3 (#NLRP3) inflammasome and decreases renal tubular epithelial-to-macrophage crosstalk in a model of diabetic kidney disease biosignaling.biomedcentral.com/articles/10....
👇👇👇 #hemichannels #connexin #inflammation #NephSky