Olga Soutourina from @univparissaclay - #I2BC - will talk about alternative to current antibiotics & antivirals at the 9th edition of Immunotherapies & Innovations for Infectious Diseases congress, organized by MabDesign 13-14 November 25 - ENS, Lyon, Fr i4id.org
#Immunotherapy #InfectiousDiseases

Introducing #I2BC for its 10 years anniversary

This work has been done at #I2BC @cnrsbiologie.bsky.social @cnrs-paris-saclay.bsky.social @i2bcparissaclay.bsky.social

Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling - Nature Communications Here, using ribosomal profiling, the authors characterize the translatome of HIV-1 revealing tens of alternative open reading frames (ARF) that encode conserved viral antigens and show that ARF-derive...

I am very pleased to share with you this fantastic work done in in collaboration with Arnaud Moris’steam. It has been a very pleasant collaboration and a fantastic project done at the #I2BC. #microproteine #riboseq #HIV www.nature.com/articles/s41...

Regulation of DNA Topology in Archaea: State of the Art and Perspectives DNA topoisomerases are ubiquitous enzymes that play a crucial role in regulating DNA supercoiling which affects fundamental biological processes involving DNA. In this review, we summarize the curren....

I am happy to share that the review my former PhD student Paul Villain and I wrote was published: doi.org/10.1111/mmi....
#Archaea
#I2BC

I am taking advantage of the arrival of @i2bcparissaclay.bsky.social to remind #I2BC members that if you are not already listed in the starter pack please contact me.

go.bsky.app/Kjf7vCa

Sexual reproduction is controlled by successive transcriptomic waves in Podospora anserina Despite the inherent challenge of finding suitable mating partners, most eukaryotes use sexual reproduction to produce offspring endowed with increase genetic diversity and fitness. The persistence of...

And another preprint this week! 🍄🎉
This time it's about gene expression from fertilization to spores formation in our favorite fungus #Podospora anserina.

#parissaclay #i2bc

www.biorxiv.org/content/10.1...

I2BC Paris-Saclay

Last month of the year! 🎊 Amazing things happened at #GenomeBiologyI2BC
in 2024. Check out our #I2BC Scoop-it and see for yourself:
www.scoop.it/topic/i2bc-p...

Genetic differentiation in the MAT-proximal region is not sufficient for suppressing recombination in Podospora anserina Recombination is advantageous over the long-term, as it allows efficient selection and purging deleterious mutations. Nevertheless, recombination suppression has repeatedly evolved in sex chromosomes and mating-type chromosomes. The evolutionary causes for recombination suppression and the proximal mechanisms preventing crossing overs are still poorly understood. Several hypotheses have recently been suggested based on theoretical models, and in particular, that divergence could accumulate neutrally around a sex-determining region and reduce recombination rates, a self-reinforcing process that could foster progressive extension of recombination suppression. The ascomycete fungus Podospora anserina is an excellent model for investigating these questions. A 0.8 Mb region around the mating-type locus is non-recombining, despite being collinear between the two mating types. This fungus is mostly selfing, so that strains are highly homozygous, except in the non-recombining region around the mating-type locus that displays differentiation between mating types. Here, we generated a mutant to test the hypothesis that sequence divergence alone is responsible for recombination cessation. We replaced the mat- idiomorph by the sequence of the mat+ idiomorph, to obtain a strain that is sexually compatible with the mat-reference strain and isogenic to this strain in the MAT-proximal region. Crosses showed that recombination was still suppressed in the MAT-proximal region in the mutant strains, indicating that other proximal mechanisms than inversions or mere sequence divergence are responsible for recombination suppression in this fungus. This finding suggests that selective mechanisms likely acted for suppressing recombination, as the neutral model does not seem to hold, at least in this fungus. ### Competing Interest Statement The authors have declared no competing interest.

Happy to see our last preprint online! We show that a mysterious recombination inhibition persists even with identical sequences on both mating-type chromosomes in our favorite fungus #Podospora anserina.

www.biorxiv.org/content/10.1...

#universiteparissaclay #i2bc #ideev #cnrs

This work has been done at #I2BC at the #CNRS on the university Paris Saclay campus.

Work with Ikram Mahmoudi, Chloé Quignot, Carla Martins,
funded by @agencerecherche.bsky.social
and performed at #I2BC @cea-joliot.bsky.social @cnrs.bsky.social Paris-Saclay

RNAprotDBgroup1 ECOD arch-name: a+b two layers; a/b three-layered sandwiches RFAM family: tRNA RFAM clan: tRNA clan Ribosome? no Group size: 2group2 ECOD arch-name: a+b two layers RFAM family: RFAM c...

The data can be explored interactively at bioi2.i2bc.paris-saclay.fr/django/rnapr...
thanks to the #I2BC bioinformatics facility

The PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium Abstract. Ciliates undergo developmentally programmed genome elimination, in which small RNAs direct the removal of transposable elements (TEs) during the

doi.org/10.1093/nar/...
Glad that our lab contributed to this collaborative work with the Duharcourt and Nowak teams.
#paramecium #sRNA #GenomeBiology #I2BC #ParisSaclay

3D illustration of our work on norovirus NS4 self-assembles into various membrane-bridging multimers https://doi.org/10.1016/j.jbc.2024.107724

Different virus capsid size

3D Illustration of lanreotide nanotubes observed in cryoEM https://doi.org/10.1073/pnas.2120346119

Molecular dynamic simualtion Snapshot of a membrane donut with a carbone nanotube inserted.

First post #HelloESR 😉
Chercheur #CNRS qui a fraichement eu son poste à l' #I2BC , je fais de la modélisation moléculaire (mostly #AlphaFold) et simulations principalement sur des protéines virales des virus des hépatites E et C ☺️
Je m'éclate aussi de temps en temps avec #Blender 😋

go.bsky.app/Kjf7vCa

I made this starter pack for #I2BC members. If you are not on the list, sorry. Please contact me I will add you 😉 (corrected)

The ribosome profiling landscape of yeast reveals a high diversity in pervasive translation - Genome Biology Background Pervasive translation is a widespread phenomenon that plays a critical role in the emergence of novel microproteins, but the diversity of translation patterns contributing to their generati...

I am. Dry happy to present you, our recent paper in collaboration with Anne Lopes from #I2BC about the translational landscape of #microproteins in yeast. A great work showing how much the genome is pervasive.

genomebiology.biomedcentral.com/articles/10....

At the #I2BC we are ready for 🎄Christmas🎄Don’t forget your Christmas pullover for next Dec 14th!

La science taille XX Elles - exposition et rencontre Seize portraits grands formats de femmes scientifiques franciliennes sont à découvrir à la Médiathèque George Sand à Palaiseau à partir du 8 mars 2022 et jusqu’au 2 avril 2022. Cette exposition invite à la découverte de femmes avec des parcours scientifiques fascinants et variés.

#I2BC #sciences #DroitsDesFemmes

iledefrance-gif.cnrs.fr/fr/evenement/l…

Vaccin anti-Covid: un réel espoir ? - 10/11 VIDÉO - C'est une nouvelle étape encourageante dans la bataille contre le Covid-19. Lundi, le laboratoire américain Pfizer a annoncé que le vaccin sur lequel il planche est "efficace à 90%" contre les infections au Covid-19. Et ce, en deux injections, car la seconde se ferait trois semaines après la...

Intervention de Yves Gaudin #CNRS #I2BC #COVID19

bfmtv.com/replay-emissio…

Great paper from Boccard lab #I2BC in @CellReports

x.com/VSLioy/status/…