The global incidence of #intrahepatic cholestasis of pregnancy in singleton pregnancies is estimated to be between 0.5% and 5%, and varies extensively according to geographical area and ethnicity.
https://www.nature.c #IntrahepaticCholestasis #PregnancyComplications

Gestational hypercholanemia suppresses pregnancy‐associated adipose mass increase and stimulates a pro‐inflammatory environment in mice Women with intrahepatic cholestasis of pregnancy (ICP) have hypercholanemia alongside an increased risk of dyslipidemia. We investigated how cholic acid (CA) supplementation in murine pregnancy impac....

This new paper examines how #hypercholanemia disturbs #pregnancy related adipose tissue expansion and mRNA expression in late gestation in mice, with implications for #intrahepatic #cholestasis of pregnancy.
doi.org/10.14814/phy...
#Adipose #Physiology #Inflammation