Intrahepatic #cholestasis of pregnancy is the most common pregnancy-related #liverdisease, manifesting typically during the third trimester of pregnancy with pruritus and elevated serum bile acids https://www.nature.c

We are sharing Paulene's story with #postpartumpreeclampsia #twins #cholestasis #gestationaldiabetes

"I was having a really bad headache, and just not feeling right. I took my BP at home and it was 190/120"

Read more: www.preeclampsia.org/our-stories/...

Intrahepatic #cholestasis of pregnancy is the most common gestational liver disease, typically manifesting in the second or third trimester with pruritus and elevated total bile acid levels, associated with hormonal and genetic factors.
https://www.nature.c #Pruritus

During #cholestasis inpregnancy, the increased maternal serum bile acid (BA) concentration leads to a higher flux of BAs from the maternal to the fetal compartment.
https://www.nature.c

Ipsen’s Iqirvo accepted by SMC to treat rare liver disease primary biliary cholangitis - PMLiVE The life-long condition affects approximately 1,900 people in Scotland

#hepatology #gastroenterology #Ipsen #Iqirvo #elafibranor #SMC #ScottishMedicinesConsortium #SMCapprovel #liverdisease #primarybiliarycholangitis #Scotland #NHSScotland #rarecholestaticliverdisease #NICE #NICErecommended #PBCpatients #ELATIVEtrial #cholestasis
pmlive.com/ipsens-iqirv...

Pathologic and therapeutic insights into cholestatic liver disease-associated depressive disorder Uncover neuroendocrine links in cholestasis-induced depression: bile acid accumulation disrupts the BBB and gut-brain axis, revealing new therapeutic targets.

New review: How does cholestasis trigger depression? Discover how bile acids disrupt the BBB, drive neuroinflammation, and affect the gut-brain axis. Learn more: amm-journal.org/index.php/20...

#Cholestasis #DepressionResearch #Neuroendocrine #GutBrainAxis #LiverDisease

Defying distance, Dr. Krupa Mysore virtually presented her amazing #hepatology research!

Looking at #cholestasis, she delved into the relationship between bile acids and immune response, describing how different immune cells are affected by these bike acids.

Dr. Greg Guthrie kindly shared some early work from his latest project!

The introduction to a beautiful story beginning to be told, he touched on the microbiome, gut, and liver through a #neonatal #cholestasis lens. His talk inspired fabulous conversation, as well!

🏥 Symposium Spotlight 🏥

With #pediatric #hepatology expertise both clinically and in the lab, Dr. Krupa Mysore works as both a transplant hepatologist and research scientist at Texas Children's Hospital! She tackles many liver-related topics, including #cholestasis, #immunology, and more.

🐷 Symposium Spotlight 🐷

Working with Dr. Doug Burrin's lab at Houston's Children's Nutrition Research Center, Dr. Greg Guthrie examines the intricacies of #cholestasis in #neonates using piglets as a model, including the effects of bile acids, lipid emulsions, and parenteral nutrition.

Gestational hypercholanemia suppresses pregnancy‐associated adipose mass increase and stimulates a pro‐inflammatory environment in mice Women with intrahepatic cholestasis of pregnancy (ICP) have hypercholanemia alongside an increased risk of dyslipidemia. We investigated how cholic acid (CA) supplementation in murine pregnancy impac....

This new paper examines how #hypercholanemia disturbs #pregnancy related adipose tissue expansion and mRNA expression in late gestation in mice, with implications for #intrahepatic #cholestasis of pregnancy.
doi.org/10.14814/phy...
#Adipose #Physiology #Inflammation

Just given a presentation on ICP to student midwives and there were some great questions! Here's one of the slides I used in the presentation.
#liver #pregnancy #itching #ItchingInPregnancy #cholestasis

Third patient this week with post #COVID #cholestasis. I am truly surprised at the paucity of literature on this topic. Maybe an opportunity for a twitterverse collab!