Advanced lipidomic techniques for high-throughput profiling of complex sphingolipids in plant tissues - Journal of Plant Research Journal of Plant Research - Sphingolipids are essential membrane components that regulate various cellular functions by forming ordered domains. The structural core of sphingolipids comprises a...

“Advanced lipidomic techniques for high-throughput profiling of complex sphingolipids in plant tissues.” Ishikawa #Sphingolipid #Lipidome #OpenAccess link.springer.com/article/10.1...

The Martini 3 Lipidome: Expanded and Refined Parameters Improve Lipid Phase Behavior Lipid membranes are central to cellular life. Complementing experiments, computational modeling has been essential in unraveling complex lipid-biomolecule interactions, crucial in both academia and industry. The Martini model, a coarse-grained force field for efficient molecular dynamics simulations, is widely used to study membrane phenomena but has faced limitations, particularly in capturing realistic lipid phase behavior. Here, we present refined Martini 3 lipid models with a mapping scheme that distinguishes lipid tails that differ by just two carbon atoms, enhancing the structural resolution and thermodynamic accuracy of model membrane systems including ternary mixtures. The expanded Martini lipid library includes thousands of models, enabling simulations of complex and biologically relevant systems. These advancements establish Martini as a robust platform for lipid-based simulations across diverse fields.

Our collaborative work "The #Martini3 #Lipidome: Expanded and Refined Parameters Improve Lipid Phase Behavior" is now published in #ACSCentralScience! 🎉

📄 Read: pubs.acs.org/doi/10.1021/...

💾 GitHub: github.com/Martini-Forc...

#MolecularDynamics #Biophysics #Simulations #Lipids

Share your research for a chance to showcase your poster at our Lipids meeting! Submit by 11:59pm MST on March 13 & connect with leading experts like Marcus Conrad in Breckenridge, CO, USA.

#KSLipids25 #lipidomics #lipidome #lipidsignaling #lipidmetabolism #lipidMAPs youtu.be/6Dm6Dryk1Lk

We didn't find many differences in the #Proteome or #Lipidome than correlated with sensitivity to inflammation.

But #Leukocytes from resilient and sensitive showed clear differences in their responses, including in genes linked to LPS metabolism.

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The #Martini3 #Lipidome represents a significant leap forward in molecular simulation of lipids, providing unprecedented structural resolution for Martini lipid models, refinements on bonded terms, an expanded lipid library, and enhanced phase behavior accuracy.