HIV treatment regimens may exacerbate risk of knee arthritis Lopinavir treatment accelerated chondrocyte degradation and promoted senescence, a process in which cells permanently cease growth and division, thereby contributing to osteoarthritis development.

#PLHIV (including #LGBT) health in focus: #Lopinavir treatment for people with #HIV accelerated chondrocyte degradation and promoted senescence, where cells permanently cease growth and division, thereby contributing to #osteoarthritis development.
outragemag.com/hiv-treatmen...

Publications des données de l'essai de l'OMSConfirme le pas ou peu d'effet du #remdesivir chez les patients hospitalisés

Pas d'effet non plus de #hydroxychloroquine #lopinavir #interferon

thelancet.com/action/showPdf…

Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial In patients admitted to hospital with COVID-19, lopinavir–ritonavir was not associated with reductions in 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death. These findings do not support the use of lopinavir–ritonavir for treatment of patients admitted to hospital with COVID-19.

L'association #lopinavir #ritonavir ne marche pas dans la #Covid_19 .
Avec des IC50 de 10 µM dans le (mauvais) modèle des cellules vero et 20 µM sur cellule humaine... il n'y avait aucune chance

C'était annoncé en juillet.. c'est publié #recoverytrial

thelancet.com/journals/lance…

No clinical benefit from use of lopinavir-ritonavir in hospitalised COVID-19 patients studied in RECOVERY Statement from the Chief Investigators of the Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial on lopinavir-ritonavir, 29 June 2020

Confirmation par #recovery de l’absence d’intérêt du #lopinavir #ritonavir #Covid_19

recoverytrial.net/news/no-clinic…