Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

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#Matrigel #Endoderm #EvoDevo #mESCs #stembryo

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide - Nature Structural & Molecular Biology Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA methylation and increases in 5-hydroxymethylcytos...

Epigenetics Update - OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide go.nature.com/4laK9MG

#Epigenetics #DNAdemethylation #mESCs
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Gain deeper insights into gene regulation; epigenometech.com