Melanomas arising in blue nevi exhibit absence of TERT promoter mutations, low tumor mutational burden, and high frequency of distant metastases and disease-related mortality: a clinicopathologic and ... Melanoma arising in blue nevus (MBN) is a rare melanoma subtype with distinct molecular characteristics and biological behaviors compared to other cutaneous melanomas. However, limited data exists on ...

🚨 Hot off the press! What a timely delivery during #USCAP2026. This is one of the very first molecular characterizations of true MBNs in one of the largest cohorts ever studied. Open access. Check it out if you love #dermpath & #molepath! 😆🔬🧬 #MDACCPath

link.springer.com/article/10.1...

Melanoma With RNF11::BRAF Fusion: A Novel Fusion Previously Undescribed in Melanoma - PubMed B-Raf Proto-Oncogene ( BRAF ) fusions are rare in melanomas. We present a case of cutaneous melanoma with a Ring Finger Protein 11 ( RNF11 ) ::BRAF fusion in a 63-year-old man with a history of stage IB melanoma on the right upper back (pT2apN0cM0; nonulcerated with a Breslow thickness of 1.2 mm). D …

The presence of a gene fusion doesn’t always indicate a Spitz melanocytic neoplasm. Here’s our example featuring the new RNF11::BRAF fusion in non-Spitz melanoma. Check it out if you love #dermpath and #molepath! 😆🔬🧬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/40036483/

Atypical Spitz Tumor/Spitz Melanocytoma Revealing a VIM::NTRK3 Gene Fusion: Clinicopathological Correlation of a Unique Molecular Finding - PubMed Spitz tumors are a heterogeneous group of melanocytic neoplasms ranging from benign Spitz nevi to malignant Spitz melanomas, with atypical Spitz tumors/Spitz melanocytoma occupying an intermediate position within this biological spectrum. A hallmark of all these lesions is the presence of specific g …

Bit late in sharing this, but excited nonetheless! Here’s a report featuring another novel fusion, VIM::NTRK3, in a Spitz neoplasm.

An educational case for anyone into #dermpath & #molepath combos! 😄🔬🧬

pubmed.ncbi.nlm.nih.gov/40591913/

NSD3::FGFR1 : A Novel Gene Fusion First to Be Described in Merkel Cell Carcinoma - PubMed Merkel cell carcinomas (MCCs) exhibit diverse molecular profiles, often categorized by their association with Merkel cell polyoma virus (MCPyV). MCPyV-associated MCCs typically display a low tumor mutational burden (TMB), lacking both somatic mutations and ultraviolet signature. By contrast, MCPyV-n …

When was the last time you encountered a gene fusion in Merkel cell carcinoma?

Here is the first documented case of MCPyV-positive MCC harboring a novel NSD3::FGFR1 gene fusion. Check it out if you love #dermpath and #molepath! 😆🔬🧬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/40036479/

Diffuse cutaneous ALK-immunoreactive histiocytosis with MEF2C::FLT3 fusion - PubMed Diffuse cutaneous ALK-immunoreactive histiocytosis with MEF2C::FLT3 fusion

We share our experience with an unusual, diffuse cutaneous ALK-immunoreactive histiocytosis with a MEF2C::FLT3 fusion. Check it out if you love the #dermpath and #molepath combination. 😆🔬🧬

#MDACCPath

pubmed.ncbi.nlm.nih.gov/41211348/

Exciting news! The May issue of The American Journal of Dermatopathology is out, and our paper is featured on the cover! What a great way to kick off the month. That gene fusion schematic? Pretty much our signature move at this point! 😆🔬🧬🎉

#dermpath #pathology #molepath #MDACCPath

Happy Friday #dermpath! 😆🔬

Two of our articles were selected as Editor’s Choices in this month’s AJDP — and one even landed the front cover, featuring this photogenic gene schematic! 🧬🎨🎉

#MDACCPath #molepath #pathology