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Applications are open for the next class of the #NephJC internship

Apply here www.nephjc.com/news/nephjc-... or scan the QR code

#ISNWCN

Announcing the NephJC Editorial Internship — NephJC Are you a curious, motivated nephrology fellow or early‑career faculty member with a passion for science communication? NephJC is inviting a small group of talented individuals to join our Editorial I...

The #ISNWCN has high trial impact clinical trials to celebrate latest and more successful results in our nephro world

To celebrate the joy of getting together, and to #NephItForward, we officially opened up the #NephJC Editorial Internship application

www.nephjc.com/news/nephjc-...

Kidney Week in Houston: Day 3 — NephJC Day 3 of Kidney Week. Sibeprenlimab and Balcinrenone on NEJM and Lancet, plus a couple of other non-kidneywk studies.

But why not use Rituximab instead

www.nephjc.com/news/2025/11...

#NephJC #ISNWCN

Lovely recap posts!, thank you!
If it helps to know for #nephjc program development, after ~8 yrs. of @nephjc.bsky.social & hypertension education, it would be quite justified to request a minimum membership fee instead of relying on optional voluntary donations- perhaps minimum $50-100/ yr 😃🤷🏼‍♀️

I read an award as The 2026 Enraged Scientist of the Year and that made me happy if only for a moment. #NephJC #NephJCKidneys

Late to the game since I was on spring break in NYC but I'd do it again twice if it could repair damage. #NephJC

Newsletter — NephJC

👀 We'll soon start looking for a new generation of interns

📍Don't miss out on the #NephJC call

💌 Subscribe to our newsletter

www.nephjc.com/newsletter

4/ Congrats to all finishing the #NephJC internship. I hope each of you leaves richer, personally or professionally.

We’ll close with @nephro_sparks’s words👇

3/ @nephrosparks.bsky.social delivered a powerful reminder of what #NephJC teaches us and what we aspire to.

🫰One line stays with us: persistence beats perfection.

2/ @brianrifkin.bsky.social recap highlighted our progress and future plans, but what stays with me is this: #nephjc never stops adapting. We keep learning, improving, and reaching for a better version of ourselves 🌟

1/ Today’s #nephjc graduation was pure joy. Seeing mentors and interns from around the world come together reminded me why this community matters.

✨Thank you for making it extraordinary

#NephJC
The #TenPostNephJC on REACT injections in DKD is live !!
Missed the chat?
Need a short recap of the study ?

We’ve got you covered !! 😃

10/10
Final #NephJC thoughts 🤔💭

Exciting science, no doubt. 👏

But between biopsies, cost, and complexity, we’re not there yet. 🤔

REACT shows where nephrology could go, not where we are today…but one can still hope. 💙

See y'all !!

9/10
I want more info:👓📖
Do go through the insightful summary by SaiVani @drsaivani.bsky.social and Akshaya @nephromommy-akshu.bsky.social
www.nephjc.com/news/rilprencel-react 🔖📖
🎨Beautiful visual abstract by @roxnonna23.bsky.social
www.nephjc.com/news/2026/3/9/react-the-visual-abstract
#NephJC

8/10
#NephJC Quote of the fortnight from @dramiliflores..bsky.social💬
When simple pills aren’t being taken uniformly, expecting a double-biopsy treatment to be adopted in a widespread manner would be almost foolish! 🌍

7/10
Chat consensus?🎬
The study is biologically exciting, showing effects on eGFR slope & appearing safe.

Seems like a magic pill (Injection rather! )

However, this was a small, phase 2, unblinded study with no hard outcomes yet. We’re interested… but not ready to change practice.

#NephJC

6/10
Give me something clever to say 🤓

💫 REACT sounds like sci-fi medicine: Regenerate your own kidney 💫
Here's a reality check via @brianrifkin.bsky.social and @nephromommy-akshu.bsky.social

👉 2 biopsies
👉 Harvest + Re-inject

Less Star Trek... More real-world hurdles 😬 #NephJC

5/10
A figure paints 🖼️ a 1000 words!
In this trial the use of the Rilparencel was assoc. with a slower ⬇️ of eGFR compared to the prior trend, in pts with advanced DKD (GFR ~ 30s, UACR ~ 400 mg/g) and a pre-infusion eGFR loss of ~ 3.4 to 5.8 ml/min/1.73m2/year. #NephJC

4/10

1 post results 📊
Rilparencel improved eGFR slope:
📉 ~4.6 ml/min/1.73m² (2-dose cohort)
📉 ~1.7 ml/min/1.73m² (conditional dosing)
Also ↓ predicted KFRE risk, with acceptable safety (biopsy-related AEs, no deaths).
Small study, but signal is intriguing 👀 #NephJC

3/10
1 Post Methods 👩‍🏫

Phase 2, multicenter, random, open-label

Autologous renal cells from biopsy → renal epithelial cells isolated → reinjected into the patient’s renal cortex

1° outcome: Δ in (acute & chronic) eGFR slope (CKD-EPI 2009) pre-injection vs post-last injection period 📉
#NephJC

2/10
What’d I miss? 👀
CKD isn’t one pathway. It’s inflammation, fibrosis, metabolic injury & hypoxia. Most drugs hit one.
Cell therapy?Targets multiple pathways at once.

If kidney transplant is gold standard for renal replacement therapy, could REACT be its preventive counterpart in DKD? #NephJC

1/10
Welcome to #TenPostNephJC
Can we move beyond slowing CKD → to actually repairing the kidney?
Last #NephJC we discussed Rilparencel, a renal autologous cell therapy (REACT) infusion and its effect on eGFR slope.

two red kidneys with arms and legs are standing next to each other Alt: two red kidneys with arms and legs are standing next to each other

Should I write an entire parody album about the parts of the kidney, yes/super yes

Brought to you by changing "Age of Aquarius" to "Macrophage of Glomerulus" #kidneycrew #nephjc

Bleeding prevention with desmopressin for allograft kidney biopsies: a double-blind randomized study AbstractBackground. Percutaneous kidney allograft biopsy is essential for evaluating graft dysfunction, but post-procedural bleeding remains the most frequ

Yet another ddAVP trial for kidney biopsies with neutral results

academic.oup.com/ckj/advance-...

In Clinical Kidney Journal

Previous #NephJC discussion: www.nephjc.com/news/ddavp

Bleeding Risk in Patients Receiving Omega‐3 Polyunsaturated Fatty Acids: A Systematic Review and Meta‐Analysis of Randomized Clinical Trials There is a potential concern about increased bleeding risk in patients receiving omega‐3 polyunsaturated fatty acids (PUFAs). The aims of this study‐level meta‐analysis were to determine the risk of bleeding and to assess whether this relationship ...

Omega-3 may increase bleeding risk
Probably safe when no procedure is planned, but less reassuring in high⚠️ biopsy patients, issue still under study.
If injecting therapies directly into the renal cortex, I would likely avoid omega-3 to reduce any issue #nephjc

pmc.ncbi.nlm.nih.gov/articles/PMC...

What risks of 🐠 #NephJC do u mean here @dramiliflores.bsky.social ?

two men with long hair and glasses are standing next to each other with the words " not one but two " on a green background ALT: two men with long hair and glasses are standing next to each other with the words " not one but two " on a green background

Really 2 biopsies!
Harvest and re-inject. #NephJC

Awesome, thanks for all the hard work #nephjc

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