also see the #NephTrials discussion of this and cluster RCTs here www.nephjc.com/news/clusterct
Blog from @manasib33.bsky.social

From single shots to strategy: How CAPTIVATE is reframing the NephTrials playbook — NephJC Summary of the CAPTIVATE platform which will be a twitter spaces discussion

CAPTIVATE= phase 3, adaptive, platform RCT #NephTrials #NephJC

🎯 Find the best treatment, or combo, that 🐌 CKD progression

✍️Blog @nephroseeker.medsky.social @sayalibthakare.bsky.social ‪
@dramiliflores.bsky.social

Reviewed by @hswapnil.medsky.social , S. Kotwal
www.nephjc.com/news/nephtri...

⏰ Happening in 3 and a half hours

Let's talk methodology 😉

🔥 This trial will CAPTIVATE any nephrologist: it's a multi-centre, phase 3, adaptive, and platform trial

#NephTrials #NephSky #MedSky

Scheduled: Nephtrials - CAPTIVATE: Finding treatments to slow the CKD progression Int Society of Nephrology’s Space · Where live audio conversations happen

𝗧𝗢𝗗𝗔𝗬: Join us & @nephjc.bsky.social for #NephTrials as we discuss CAPTIVATE.
🗣️ Sradha Kotwal, @hswapnil.medsky.social, @kidneyboy.bsky.social, @dilushiwijay.bsky.social Manjusha Yadla
🕘 9 pm EST
Join: twitter.com/i/spaces/1gq...
Read: www.nephjc.com/news/nephtrials-captivate

The Global Kidney Patient Trials Network and the CAPTIVATE Platform Trial Design This trial protocol identifies the design and baseline results of the Global Kidney Patient Trials Network (GKPTN) and the global adaptive platform randomized clinical trial Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect (CAPTIVATE) to find new...

Busy schedule coming for #NephJC

🗓️June 26th, 2025
#Nephtrials discussing the fascinating design of the CAPTIVATE platform clinical trial

jamanetwork.com/jour...

🚀Space on twitter
x.com/i/spaces/1gqGv...

Figure 3:Simplified schematic of a platform trial.

Lastly the authors also come out in favor of platform trial designs

See #NephTrials discussions here: www.nephjc.com/news/beat-ca...
And here:

www.nephjc.com/news/master-...

#NephSky 4/4

Figure 1:Key streamlined trial design features.

They call this ‘streamlined’ trials - seems like the pragmatic trial feature we discussed on #NephTrials here: www.nephjc.com/news/2021/2/...

#NephSky
2/

Characteristics and limitations of the HDF trials

It’s such a mix of high quality and poor quality studies that I am not sure the metaanalysis adds much

@manasib33.bsky.social broke it down for #NephTrials here www.nephjc.com/news/2022/9/...

NephTrials: Basket Trials, Umbrella Trials, and the RENAL LIFECYCLE trial — NephJC master trials umbrella trials platform trials basket trials RCT methodology flozins SGLT2 inhibitors NephTrials RENAL LIFECYCLE Dapagliflozin

We chatted about these previously on #NephTrials here

www.nephjc.com/news/master-...

And

www.nephjc.com/news/beat-ca...

#NephSky

Pragmatic trials in nephrology: Bridging the gap between efficacy and effectiveness? — NephJC pragmatic trials, rcts, rct, phosphate, ckd, kidney, trial design, tweetchat

More on pragmatic trials and PHOSPHATE trial in particular here from Manasi Bapat for #NephTrials

www.nephjc.com/news/2021/2/...

N of 1 trials
Basket Trials multiple diseases same intervention
Umbrella trials same disease, different intervention
Platform trial: multiple interventions modified over time as data is accumulated.
#NephTrials

#KidneyWk

The PROTECT-V platform - RENALISM no more? — NephJC This week on NephTrials we will discuss the PROTECT-V trial, a platform trial for preventing COVID-19 infections in the vulnerable kidney populations.

On Monday we discussed the topic of platform trials with the discussion anchored by the PROTECT-V trial

Touching upon #COVID #PlatformTrials and #Renalism

This was the #NephTrials initiative - a joint NephJC - ISN project

www.nephjc.com/news/protect-v

x.com

Time to plug in your AirPods and join the #Nephtrials Space. We are trying something different with Twitter. Let's go into live audio! https://x.com/i/spaces/1YqKDgDLgeNxV

BEATing  Calciphylaxis with an Adaptive Platform design — NephJC This week on #NephTrials, we will discuss platform trials, anchoring the discussion to the BEAT-Calci trial, which has a number of interesting design features.

𝗧𝗢𝗗𝗔𝗬: #NephTrials, an ISN-NephJC joint discussion on "The BEAT-Calci Trial."

🕒 9 pm EST
📖 Warm up with the blog post: nephjc.com/news/beat-ca...

I'm going to work on my own QoL by going for a run. #NephTrials thanks for the education

According to @fperrywilson's How Medicine Works and When it Doesn't, there are only three outcomes that really matter:

1. Death
2. Birth
3. Quality of life

#NephJCBookClub
#NephTrials

Hi! I'm Cristina Popa, Romanian nephrologist fighting against my every instinct to not fall asleep (4 am& unmeasurable sleep in the last 72 h) #NephTrials
The essence: what would my pts would choose? The scientific illusion of a hard endpoint or reality of a little better QoL?

Joel Topf, community nephrologust abnd #NephJC co-founder ready to pretend I know something about clinical trial design as part of #NephTrials

The numbers: 280 Tweets. 34 Participants. 3,125,321 Impressions. March 9th 2023. More #NephTrials 📊 here www.symplur.com/healthcare-hashtags/Neph... via @symplur

Hi! Cristina Popa here, Romanian nephrologist. On call, with a basket of CKDs in ED. 🚨 Hopefully I will be lurking 🤞#Nephtrials #NephJc

Just getting set up here. Sorry I'm late. #NephTrials

And predictions from @SRNefro and @accovic, CONVINCE trial will be negative (because it included older people with high comorbidities), but most probably it will have a positive subgroup analysis

For more details see #NephTrials discussions...

Nice chat. Thanks. #NephTrials

If we get clear and convincing evidence that HDF leads to better survival we will need to apply maximum pressure to Davita, Fresenius, and the US Government to make it widely available in the US. #NephTrials

What are the primary compromises that had to be made to the protocol because of using the registry? #NephTrials

Hi! Cristina Popa, Romanian nephrologist, lurking from dialysis shift, where I might have patients on HD or HDF. No COIs #Nephtrial #NephJc #Nephtrials

Back from the dog walk. Tready to dig in to #NephTrials

Acetaminophen would score high on QoL for influenza but no one calls it a therapy for influenza. #nephTrials

Worry that pragmatic trial may miss small benefits that get swallowed by heterogeneity in execution of intervention. (Am I thinking about this right?) #NephTrials

Joel Topf, #NephTrials. I'm a pragmatic guy but I don't know what a pragmatic trial is.