Exploring the omnigenic architecture of selected complex traits Core genes identified for ulcerative colitis, coronary artery disease, and other traits by a multi-modal graph machine-learning pipeline are expressed in disease-relevant tissues. Core genes demonstra...

Cool method to exploring the #omnigenic architecture of complex traits
www.cell.com/ajhg/fulltex...

GitHub - biostatShao/HVAC: Hierarchical Bayesian model with Variational inference and functional Annotation integration for Cross-ancestry prediction Hierarchical Bayesian model with Variational inference and functional Annotation integration for Cross-ancestry prediction - biostatShao/HVAC

HVAC

by Zhonghe Shao
for cross-ancestry polygenic score #PGS derivation based on the #omnigenic model, incorporating functional annotation across multiple omics layers though hierarchical #Bayesian modeling

github.com/biostatShao/...

This festive season 🎄 give the gift 🎁 of a #bayesian model to a friend still trying to run a frequentist linkage mapping approach looking for significant associations 🧬🖥️
#genomics #QuantitativeGenetics #polygenic #omnigenic