#slidearchiveseries chromophobe renal cell carcinoma #gupath #pathsky #pathoutpic

✅ solid sheet-like architecture
✅ plant-like cell borders (vegetable cells)
✅ irregular, wrinkled nuclei (raisinoid)
✅ binucleation and perinuclear halos
🎨 CK7, CD117, Hale colloidal iron

#macrovsmicro total nephrectomy, tan to red, nodular, heterogeneous, well-delineated, focally hemorrhagic/necrotic mass #gupath #pathsky #pathoutpic #kidneytumor

#slidearchiveseries urinary bladder, inflammatory myofibroblastic tumor #gupath #pathsky #pathoutpic

🔬 Diverse patterns: myxoid, fascicular, hyalinized
🎨 ALK IHC (diffuse cytoplasmic) in 40-60%
🧬 50-60% ALK fusions (EML4, TPM3/4, CARS, RANBP2, IGFBP5…)

#slidearchiveseries seminoma with brisk lymphocytes, rete testis invasion, and GCNIS—classic 'fried egg' 🍳 appearance with a dash of pepper #gupath #testistumor #pathoutpic

#macrovsmicro orchiectomy, tan-white, firm, homogeneous, faintly lobulated, well-delineated mass abutting the rete testis #gupath #pathsky #pathoutpic

🩺 increased testicular pain and swelling, evaluation for torsion; 3.9 cm mass on ultrasound 🧪 AFP 3.8, HCG 2.5

#slidearchiveseries chromophobe carcinoma with sarcomatoid differentiation #gupath #pathsky #pathoutpic

⚠️ sarcomatoid component may overrun the epithelial component, extensive sampling may be needed to identify recognizable carcinoma

#slidearchiveseries mixed germ cell tumor, predominantly embryonal carcinoma with smaller components of yolk sac tumor and teratoma, LVI present (additionally confirmed with ERG immunostain) #gupath #pathsky #pathoutpic

#slidearchiveseries urothelial carcinoma, clear cell (glycogen-rich) #gupath #pathsky #pathoutpic

🎨 IHC profile similar to conventional urothelial carcinoma (GATA3, p63)
⚠️ distinguish from metastatic CCRCC and clear cell adenocarcinoma

#slidearchiveseries urothelial carcinoma, plasmacytoid variant #gupath #pathsky #pathoutpic

🧐 special attention during frozen section, frequent positive surgical margins along the ureters and periureteral soft tissue that may appear grossly negative 😰🤯

🎯 metastatic renal medullary carcinoma
🔬reticular, cribriform, and cord-like patterns; intratumoral inflammatory infiltrate (sometimes abscess forming); fibrotic stroma with myxoid areas
✨ metastasis common to lung, liver, LN, adrenal gland, RP, etc #gupath #pathsky #pathoutpic

#slidearchiveseries SMARCB1 deficient renal medullary carcinoma
#gupath #pathsky #pathoutpic

🩸 young pts with sickle cell trait
🔬 cribriform, reticular, nested growth
🎨 PAX8, broad spectrum CKs, CEA, p53
⚠️ OCT3/4 ➕ (50%), pitfall with GCT
🔑 SMARCB1 / INI1 inactivation

#slidearchiveseries urothelial carcinoma, plasmacytoid variant #gupath #pathsky #pathoutpic

🔬discohesive single tumor cells, eccentrically placed nuclei, eosinophilic cytoplasm 
💥high grade, poor prognosis
🙅🏻‍♀️do not use CD138 in isolation to distinguish from plasma cells

#slidearchiveseries keratinizing squamous cell carcinoma of the bladder #gupath #pathsky #pathoutpic

☝🏼assoc with keratinizing squamous metaplasia / dysplasia of the mucosa
✌🏼exclude urothelial ca with squamous diff, spread from primary (cervix, penis, anus) or metastasis

#slidearchiveseries scrotal calcinosis
#gupath #dermpath #pathsky #pathoutpic

🔬intradermal nodules varying in size and number, foreign body giant cell reaction in surrounding tissue
📊 differentials include calcification of epidermal or pilar cyst
🤔 idiopathic or dystrophic

#slidearchiveseries paratesticular embryonal rhabdomyosarcoma #gupath #BSTpath #pathsky #pathoutpic

🔬 moderately cellular with loose, myxoid stroma
✨focal areas of diffuse anaplasia, atypical mitotic figures
🎨 MyoD1, myogenin, desmin
🧬 FOXO1 gene rearrangement negative

#macrovsmicro gray-white, fleshy to whorled, focally hemorrhagic and bosselated paratesticular mass #gupath #BSTpath #pathsky #pathoutpic

#slidearchiveseries papillary renal neoplasm with reverse polarity #gupath #pathsky #pathoutpic

🕵🏻‍♀️ usually asymptomatic, incidentally found, clinically indolent
🔬 thin papillary/tubulopapillary growth, apically located, low grade nuclei
🎨 CK7, GATA3, L1CAM
🧬 KRAS mutation

#slidearchiveseries nephrogenic adenoma #gupath #pathsky #pathoutpic

🏥 prior urothelial injury (surgery, calculi, trauma)
sites: bladder > urethra > ureter
🔬 metaplastic lesion, multiple morphological patterns
🎨 PAX8, AMACR, GATA3 (40%), PSA (weak) (+)
⚠️ exclude prostate & bladder ca

#slidearchiveseries urothelial carcinoma, micropapillary subtype #gupath #pathsky #pathoutpic

☝🏼distinguish from retraction artifact
✅ multiple small nests floating within single lacunae
✅ back-to-back lacunae
✅ presence of ring formations

#slidearchiveseries urothelial carcinoma, micropapillary subtype
#gupath #pathsky #pathoutpic

🔬 small tumor cell clusters without fibrovascular cores, floating in lacunar spaces
⚠️ may resemble vascular invasion

#slidearchiveseries urothelial carcinoma with extensive squamous differentiation #gupath #pathsky #pathoutpic

☝🏼 identifiable urothelial component (may only be carcinoma in situ)
✌🏼 recommended to report percentage of squamous component

#slidearchiveseries eosinophilic solid and cystic renal cell carcinoma #gupath #pathsky #pathoutpic

🔬 solid and cystic architecture, basophilic intracytoplasmic stippling, and eosinophilic inclusions
🎨 PAX8+, frequently CK20+, usually CK7-/CD117-, majority Cathepsin K+

#slidearchiveseries clear cell renal cell carcinoma with rhabdoid features #gupath #pathsky #pathoutpic

🔬 large eccentric nuclei with prominent nucleoli, abundant eosinophilic cytoplasm, globular eosinophilic intracytoplasmic inclusions

#slidearchiveseries papillary renal cell carcinoma #gupath #pathsky #pathoutpic

🔬 small cuboidal cells arranged in a single layer around papillary cores containing nests of foamy macrophages
🧬 chr 7 and 17 gains, loss of Y; MET gene mutations (PMID: 26536169, 10433944)

Colloidal iron

chromophobe renal cell carcinoma showing its true colors! #gupath #kidneytumor #pathsky #pathoutpic
🎨 collodial iron special stain 🔵💥