Feasibility Trial of Prolonged versus Single-Dose Challenge in Penicillin Allergy We aimed to evaluate the feasibility of conducting a multicenter, double-blind, placebo-controlled trial of prolonged (i.e., multidose) compared with single-dose amoxicillin challenge in patients w...

#PROSPECTOR Trial is out in NEJM Evidence 🔥

➡️ evidence.nejm.org/doi/full/10....

✅ 1st double-blind, placebo RCT in #drugallergy
✅ Pilot feasibility RCT
✅ 1-dose vs 5-day amoxicillin challenge in delayed/unknown #penicillinallergy

We’re going to answer… Is 1 dose ever enough? 👀 #PROSPECTOR2

Improving access to penicillin allergy evaluation for millions of older patients could improve antibiotic treatment and reduce surgical site infections and C. diff. The Penicillin Allergy Verification and Evaluation Act could help. https://ow.ly/alV250Y8oyt

#PenicillinAllergy

JAMA Network Open article: "Disagreement Between Allergist and Electronic Health Record Documentation of Penicillin Allergies" by Theresa B. Dunham and Kimberly G. Blumenthal, published online December 19, 2025.

Discrepancies between allergist assessments and #EHR documentation of #PenicillinAllergy persist, with nearly half of cases in a recent study showing disagreement, especially in risk classification. ja.ma/48YLuRC

The cost-effectiveness of penicillin allergy testing: Evidence and gaps from a systematic review.
Ahmed, Shadia et al.
Paper
Details
#PenicillinAllergy #CostEffectiveness #SystematicReview

The largest adult #penicillinallergy study ever undertaken - The iNAAN study @thedohertyinst.bsky.social @unimelb.bsky.social - 52 hospitals, 8 countries and over 5000 patients….Real world proof of the safety and effectiveness of inpatient DOC! Stay tuned #AMS folks 👀Results soon!

Is one dose ever enough? The PROSPECTOR 🪓 Trial will answer - A international double blind placebo controlled trial of 1 dose vs 5 day for #penicillinallergy. This week we recruited our 100th patient! 🎉 @thedohertyinst.bsky.social

Members of the AAAAI Board of Directors met with key Capitol Hill offices today to advocate on issues critical to members and patients. These discussions are vital to strengthening the specialty and improving patient care.

https://www.aaaai.org/about/advocacy/sustainability

#PenicillinAllergy

Original post on med-mastodon.com

www.cbc.ca/news/canada/british-colu...

“..tool for health-care professionals to assess and identify if patients who think they have a #penicillinallergy… about 10 per cent of people report having an allergy to penicillin — but fewer than one per […]

Today is National Penicillin Allergy Day. Many patients carry a penicillin allergy label for life, but most aren’t truly allergic. Delabeling can open the door to safer, more effective treatments.
#NationalPenicillinAllergyDay #PenicillinAllergyDay #PenicillinAllergy #DrugAllergy

Did you know? More than 90% of people who believe they’re allergic to penicillin aren’t. National Penicillin Allergy Day is September 28. Together, we can improve patient safety and outcomes.

#NationalPenicillinAllergyDay #PenicillinAllergyDay #PenicillinAllergy #DrugAllergy

Drug allergy expert David Khan, MD, FAAAAI, discusses the importance of evaluating patients with reported penicillin allergy and how allergists can partner with other healthcare providers to make sure all the patients with this label are evaluated. www.aaaai.org/professional...

#PenicillinAllergy

Congratulations Elise Mitri from NACE, Austin Health & The Peter Doherty Institute presenting the iNAAN Trial results - > 5000 pts & 1500 inpatient #penicillinallergy DOC performed. Safe irrespective of stakeholder with significant prescribing gains. Largest inpatient penicillin allergy study 👏🎉

Is one dose enough?! Great talk from Dr Rose for the #PROSPECTOR #penicillinallergy #RCT at #EAACI HK Summer School. 6.7% increase in immune mediated reactions with prolonged oral challenge. Looking forward to #PROSPECTOR2 definitive phase III study to change practice!

Excited to be at EAACI Hong Kong School 2025 Hosted by Prof Li. Can’t wait for Elise Mitri from The Peter Doherty Institute to present the #iNAAN Results - #PenicillinAllergy #delabing Global Implementation! Dr Rose will present #PROSPECTOR1 - is one dose enough to delabel penicillin allergy?!? ‼️👀

You may not really be allergic to penicillin. Here's how to find out if you are. As many as 1 in 5 Americans believe they have a penicillin allergy, but just a tiny fraction actually do. In recent years, it's gotten a lot easier to find out.

You may not really be allergic to penicillin. Here's how to find out if you are. #Science #HealthandMedicine #InfectiousDiseases #PenicillinAllergy #HealthTips #MedicalAdvice

Up to 1 in 5 Americans Think They're Allergic to Penicillin. Most Aren't. A pharmacist explains.

Up to 1 in 5 Americans Think They're Allergic to Penicillin. Most Aren't. #Science #HealthandMedicine #InfectiousDiseases #PenicillinAllergy #HealthAwareness #MedicalMyths

Almost nine in ten patients labelled allergic to penicillin had no allergy, study finds Almost 90% of people whose medical records labelled them as allergic to penicillin were not truly allergic, a study funded by the National Institute for Health and Care Research has suggested.…

Almost 90% of people whose medical records labelled them as allergic to penicillin were not truly allergic, a study funded by the National Institute for Health and Care Research has suggested
#ukpharmacy #penicillinallergy

PenicillinG #Post20 ☆ Uses ● Penicillin G is used to treat bacterial infections. ● It is effective in treating syphilis. ● It is also used for the prevention of rheumatic fever. ● Additionally, it helps prevent recurrence of rheumatic fever. ● How Penicillin G Works ● Penicillin G is an antibiotic. ● It kills bacteria by preventing the formation of their protective cell wall, which is essential for their survival. ● Without this wall, bacteria are unable to live and multiply, helping clear the infection. ☆ Common Side Effects of Penicillin G ● Pain, swelling, or redness at the injection site ● Nausea or vomiting ● Diarrhea ● Rash or skin irritation ● Itching ● Headache ● Fever ● Allergic reactions (mild forms like rash or itching) ☆ Advice for Penicillin G ● You have been prescribed Penicillin G for the treatment of bacterial infections. ● It is administered by injection into a vein or muscle, or through a drip into a vein. ● Complete the full course of treatment, even if you start feeling better. ● Stopping the medicine early may cause the infection to return and become harder to treat. ● Diarrhea may occur as a side effect, but it usually stops when the course is finished. ● Inform your doctor if diarrhea persists or if you notice blood in your stools. ● Seek medical attention immediately if you experience: • Itchy rash • Swelling of the face, throat, or tongue • Breathing difficulties ☆ What important things should I tell my doctor before starting Penicillin G? ● Tell your doctor if you have ever had an allergic reaction to Penicillin G or any similar medicine. ● Inform your doctor if you have any type of allergy, including drug, food, or environmental allergies. ● Mention if you have asthma or any breathing problems. ● Let your doctor know if you have a history of heart disease. ● Inform your doctor if you have kidney disease or any kidney-related issues. ● Share a list of all medications you are currently taking, including prescription, over-the-counter, an…

PenicillinG
#Post20

#PenicillinG #Antibiotics #BacterialInfections #SyphilisTreatment #RheumaticFeverPrevention #InjectionTherapy #HowItWorks #AntibioticMechanism #DrugSideEffects #AllergicReactions #PenicillinAllergy #MedicationGuide #CompleteTheCourse #AntibioticResistance #SafeMedicationUse

Come and find me at the Poster Hall at #ESPID2025 if you want to hear more about our project on #penicillinallergy delabelling & how it contributes to #AntimicrobialStewardship!

#ESPIDInspires

Approximately 10% of patients report an allergy to penicillin. However, the majority of patients (greater than 90%) may not truly be allergic. Most people lose their penicillin allergy over time, even those with a history of anaphylaxis. #NWHW #PenicillinAllergy
www.youtube.com/watch?v=TZWc...

Elise Mitri presenting work on safely delabeling patients with penicillin allergy at the ESCMID Global conference.

Congrats to @elisemitri.bsky.social, @trubianojason.bsky.social et al for their great work on safely delabeling patients with #penicillinallergy. Elise presenting their prospective, pharmacist-led program live at #ESCMIDGlobal
#IDSky #PharmSky #openacess

www.cmi-comms.com/article/S295...

We randomised our first patients yesterday into the #PROSPECTOR2 ⛏️ study - international superioty trail of 1 dose versus day challenge for #penicillinallergy. “Is one dose ever enough….”

Our local Prescribing in Penicillin Allergy guide has been updated after much work.
This will help us safely identify those who can tolerate penicillin, ensuring they receive the best possible treatment. #PenicillinAllergy #AntibioticStewardship #PatientSafety

Inaccurate penicillin allergy labels limit access to preferred antibiotics for immunocompromised patients undergoing hematopoietic stem cell transplants according to new research being presented at the 2025 AAAAI / WAO Joint Congress. #PenicillinAllergy #AAAAI25
www.aaaai.org/about/news/n...

1000 direct oral #penicillinallergy challenges in the prospective iNAAN study 🎉- 39 hospitals and 7 countries 😳. The largest adult penicillin challenge study! Well done @elisemitri.bsky.social 👏👏 and all collaborators! @escmid.bsky.social data coming hopefully to #ESCMIDglobal 2025!

Adult penicillin allergy programmes in Australian hospitals: a practical guide from the National Antibiotic Allergy Network - PubMed Penicillin allergy is a significant burden on patient, prescribing and hospital outcomes. There has been increasing interest in the incorporation of penicillin allergy testing (i.e. delabelling) into ...

Thought worth a share on #WAAW @ncas.bsky.social day today. A practical guide to #penicillinallergy into inpatient #AMS programs. A partner to implementation! #IDSky #MedSky
pubmed.ncbi.nlm.nih.gov/39444148/