#clostridium #perfingens All strains produce a-toxin, a lecithinase that causes damage to cell membranes. During severe sepsis with
C. perfringens, rapid hemolytic anemia may occur due to hemolysis caused by the a-toxin.
#Clostridium #perfingens #mucositis Alpha toxin activates capillary bed adhesion molecules➡️sequestration of neutrophils & platelets. Mortality 74-91% w/ survival times of few hours
Tx: penicillin+clindamycin but can be polymicrobial requiring additional agents
-Clostridia R FQ (except delafloxacin)
