Multi-omics reveal critical roles of phosphatidylcholine and sphingomyelin in antipsychotic efficacy for schizophrenia - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Multi-omics reveal critical roles of phosphatidylcholine and sphingomyelin in antipsychotic efficacy for schizophrenia

#Multiomics profiling of #schizophrenia patients identified proteins, metabolites, and genetic loci predictive of #Paliperidone efficacy, with higher #phosphatidylcholine and #sphingomyelin levels correlating with better response. @pku1898.bsky.social

#STTT: doi.org/10.1038/s413...

In a recent article, Chiaki Murakami et al. identify human #PHOSPHO1 as the elusive cytosolic #phosphatidylcholine- and #phosphatidylethanolaminephospholipaseC

➡️ doi.org/10.1002/1873-3468.70018