#Phosphoinositides show dynamic patterns that shape membrane identity and signaling. This review covers their organization in well-studied and understudied organelles — ER and nucleus — and why spatial control matters for #CellBiology, #SignalTransduction and #Disease. 👨‍🔬🔬

doi.org/10.1002/1873...

🫧 #Phosphoinositides play an essential role in #membrane biology, influencing stress response, membrane remodelling, endosomal trafficking, and more. Read about the latest advances in a new review by Carla Alemany and Etienne Morel:

➡️ doi.org/10.1002/1873-3468.70213

@membramics-lab.bsky.social

Molecular insight on the role of the phosphoinositide PIP3 in regulating the protein kinases Akt, PDK1, and BTK Protein kinases are master regulators of myriad processes in eukaryotic cells playing critical roles in growth, metabolism, cellular differentiation, and motility. A subclass of protein kinases is reg...

New review out with @jburkevic.bsky.social!
We highlight recent advances in our understanding of the role the phosphoinositide PIP3 plays in regulating the protein kinases Akt, PDK1, and BTK from a structural perspective.
#kinase #phosphoinositides

portlandpress.com/biochemsoctr...

P4-ATPase control over phosphoinositide membrane asymmetry and neomycin resistance Neomycin, an aminoglycoside antibiotic, has robust antibacterial properties, yet its clinical utility is curtailed by its nephrotoxicity and ototoxicity. The mechanism by which the polycationic neomyc...

The antibiotic Neomycin is too nephrotoxic and ototoxic to use systemically. Why is a decades-old mystery...

Until now, with a sure-to-be classic from the Graham lab at Vanderbilt. It’s all about #phosphoinositides 🤯

Your #lipidtime weekend read

www.biorxiv.org/content/10.1...

Newsroom

New project launched! 🚀 Researchers explore the role of #phosphoinositides (PIPs) in metabolic diseases. Learn more 👉 https://t.co/xA1cBaUstw or Wirkstoffradio podcast: https://t.co/XePML1RYGS
@isas_Leibniz @Leibniz_DIfE @LeibnizWGL #PIPMet @VolkerHaucke