Our discovery of novel viruses in invasive camelids in Australia leads us to propose a simple idea: RNA viruses may repeatedly evolve functional modules at the 5′ end of their genomes.

#Virology #RNAvirus #VirusEvolution
#Picornavirus #VirusDiscovery

doi.org/10.64898/202...

Bacteria As Trojan Horses To Kill Tumor Cells. Columbia and Rockefeller University researchers have bioengineered a bacterium that selectively ferries a cell-killing virus into cancer cells. #cancer #bacteria #viruses #salmonella #picornavirus #trojanhorse

Image Electron microscopy magnification ×302,400): 30–31 nm round to polyhedral viral particles (red arrow), consistent w/ #Picornavirus (coxsackievirus) seen throughout biopsy within a spindle-like sheath (black arrow)
viral particles=direct invasion of muscle tissue by virus

Parechovirus: neglected for too long? | Journal of Virology Parechoviruses belong to the large family of small RNA viruses called Picornaviridae (pico—small, RNA). Picornaviruses are clinically and economically important viruses characterized by a small icosahedral protein capsid structure that contains a single-stranded, positive-sense viral RNA genome (1). These viruses show great diversity in their host tropism, usage of viral proteins, exploitation of host lipid and protein functions at different steps of the viral life cycle, and disease manifestations in humans and other vertebrate and invertebrate hosts. The Parechovirus genus is one of the Picornaviridae family genera, which contains viruses within six parechovirus species, Parechovirus A-F, that infect multiple vertebrate species (Fig. 1). Recent parechovirus-associated pediatric disease outbreaks in different parts of the world (2–4) highlighted the importance of dedicated surveillance and a greater understanding of the biology and disease manifestations caused by these understudied viruses. In this review, we summarize the history of human and nonhuman parechovirus isolation, global seroprevalence and distribution, viral biology, and evolution, considering these factors might contribute to their host specificity, virulence, tissue tropism, pathogenesis, host immunity, and population dynamics.

Glad to highlight the importance of improving our understanding of parechoviruses. These lesser-known picornaviruses have been causing neonatal neurologic diseases in different parts of the world in recent years! #Virology #Picornavirus
journals.asm.org/doi/10.1128/...

VP3, a conserved #Picornavirus caspid protein, triggers both #Autopahgy & #Apoptosis to ⏫viral replication in host cells via a convergent TP53-BAX cascade

Gly129 VP3 is critical for binding to TP53 & TP53 phospho-translocation

Autophagy 2023
www.tandfonline.com/doi/full/10....