Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn

This study shows that MMP13 promotes the formation of #DeepVeinThrombosis (DVT) while suppressing #Podoplanin expression, thereby advancing our understanding of #Thrombosis biology & offering new insights for DVT intervention. #medsky

Read: link.springer.com/article/10.1...

Lymph node fibroblast phenotypes and immune crosstalk regulated by podoplanin activity Makris et al. show that podoplanin regulates the transcription profile of lymph node fibroblasts. Podoplanin deletion drives inflammation, disrupts lymph node architecture, and attenuates stromal/immu...

Our latest paper is finally out! We are showing the significance of the podoplanin/CLEC-2 signaling axis beyond controlling cellular mechanics and actomyosin contractility.
#fibroblasts #podoplanin #stroma #inflammation

@actonlab.bsky.social

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