📣ICYMI

Parkinson’s drug, #pramipexole, is showing real promise for treating treatment-resistant depression.
ITV Meridian covered the Pax-D story 18.07, featuring Phil Harvey, whose life changed after joining the trial.

Hopeful signs for mental health care.

Watch the segment: tinyurl.com/paxdTRD

Day 1: Motivation to develop non-ergot dopamine agonists for Parkinson’s disease (PD) with improved tolerance led to discovery of more selective synthetic agents #pramipexole &
#rotigotine

Pramipexole augmentation for the acute phase of treatment-resistant, unipolar depression: a placebo-controlled, double-blind, randomised trial in the UK In this trial involving participants with treatment-resistant depression, pramipexole augmentation of antidepressant treatment, at a target dose of 2·5 mg, demonstrated a reduction in symptoms relativ...

Important study & big step forward for treatment-resistant #depression.

48-week RCT, #pramipexole showed a ~4-point QIDS-SR benefit over placebo.

Less hype, but bigger effects than psychedelic trials, for a scalable option that’s already available to clinicians!

www.thelancet.com/journals/lan...

📣A Parkinson’s drug, #pramipexole, shows promise for #treatment-resistantdepression. In an Oxford-led, @nihr.bsky.social supported trial, patients saw major symptom relief by week 12—with effects lasting a year.

@oxfordpsychiatry.bsky.social

Read more: tinyurl.com/pramipexoleTRD

Many with treatment-resistant #depression don’t respond to #aripiprazole augmentation. A new study suggests #pramipexole may offer similar benefits, even for those who previously failed aripiprazole, with no major safety concerns. More research is needed.

journals.lww.com/psychopharma...

OMG. That is negligent. Cold turkey from #Pramipexole is dangerous. Experts recommend 6 months & opioids to help! Iron infusions are not painful. They take 15 minutes. Join #RLS-UK & have a look at their help forum.