Antibody Therapeutics (IF=4.5, Oxford University Press)
🔹 Preventing Physical and Chemical Degradation of the LABL-fc-MOGR5, a Bifunctional Peptide Inhibitor, with Formulation Development Approaches.
academic.oup.com/abt/advance-...
#DrugFormulation #Biologics #ProteinStability #CMC

Read the full application note determining the stability of common growth factors > zurl.co/lZy0j

#growthfactors #proteinstability

🚨 New study reveals amino acids stabilize proteins, offering potential solutions to manage particle stability in pharmaceuticals. This breakthrough opens paths to enhance drug formulation efficacy. Link: https://tinyurl.com/23zkrsad #ProteinStability #Pharmaceuticals #BiotechInnovation

🧱 Crystal structure shows binding on the opposite face to CDK, enabling ternary complex formation.
🧪 In cells, nanobodies act as pharmacological chaperones to restore p16 function!

#StructuralBiology #CellCycle #Nanobodies #CancerResearch #ProteinStability

New Discovery Rewrites the Rules of Protein Stability and Evolution A large-scale experiment has uncovered the fundamental rules that govern protein stability, opening the door to more rapid development of drugs and enzymes. Proteins are essential molecular machines that...

New Discovery Rewrites the Rules of Protein Stability and Evolution #Science #Biology #MolecularBiology #ProteinStability #Evolution #BiologyResearch

This application note reviews the stability of @Qkine growth factors (GM-CSF, IL-6, IGF-1, IGF1 LR3, GDNF, BMP-4, HGF NK1 and TGF-ß1 PLUS) under cell culture-like conditions.

Read the full application note > zurl.co/XG5cN

#growthfactors #proteinstability

SPIRRIG is required for BRICK1 stability and salt stress induced root hair developmental plasticity in Arabidopsis - Stress Biology Developmental plasticity is critical for plants to adapt to constantly changing environments. Plant root hairs display dramatic plasticity under different environments and therefore play crucial roles...

SPIRRIG is required for BRICK1 stability and salt stress induced root hair developmental plasticity in Arabidopsis
Chi Zhang, Jingyu Zeng ... John Schiefelbein, Fei Yu & Lijun An

link.springer.com/article/10.1...

#Actin #cytoskeleton #Proteinstability