This review explores the intricate interplay between different components of the #ImmuneMicroenvironment and the associated mechanisms in the #pathogenesis of #ADPKD, and summarizes the currently available & potential #Immunotherapeutic approaches. #RenalDysfunction #medsky

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Efficacy of Larval Therapy for Wounds: A Systematic Review and Meta-Analysis - PubMed <span><b>Background/Objective</b>: Larval therapy (LT), an intervention using live fly larvae to remove necrotic tissue and promote healing, has regained attention in order to address the growing need...

Eew…larval therapy (2004) for debridement “surgery” of extremities as opposed to blood letting (leeches) in prophylactic/ preventative use for thousands of years & discontinued later 19th C. #FYI #woundhealing #diabetes #renaldysfunction pubmed.ncbi.nlm.nih.gov/39860321/

Condensation of cellular prion protein promotes renal fibrosis through the TBK1-IRF3 signaling axis PrPC activates TBK1-IRF3 signaling to worsen renal fibrosis in mice, highlighting amlexanox as a potential therapeutic for chronic kidney disease.

#Medsky🧪 #IDsky #Immunosky #publichealth Cellular prion protein (PrPC) is primarily expressed in 🧠 & is involved in the development of CNS. PrPC is also found in other tissues, incl 🩸 & urine of individuals with #renaldysfunction
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