#slcs

The genetic interaction map of the human solute carrier superfamily | Molecular Systems Biology imageimageComprehensive genetic interaction mapping of solute carrier (SLC) transporters reveals principles of cellular transport organization and metabolic adaptation. Systematic CRISPR screening with Cas12a and Cas9 systems identified 1236 ...

Over 35,000 double knockouts revealed synthetic lethal pairs and redundancies, highlighting therapeutic targets—especially in mitochondrial #SLCs. SLC39A1, a zinc #transporter, surprisingly drives metabolic rewiring and anti-apoptotic signaling in cancer. doi.org/10.1038/s443...

The solute carrier superfamily interactome | Molecular Systems Biology imageimageProtein-protein interaction (PPI) mapping of human solute carrier (SLC) transporter superfamily. Interactions affecting SLC proteostasis were validated by a high-throughput RNAi-based protein stability and localization assay to assess ...

Highlights include #PDZ-domain roles in trafficking and degrons in stability—uncovering how #SLCs are controlled post-translationally. doi.org/10.1038/s443...

In the global survey of the SLC-protein interaction landscape we determined the protein interactions of ~400 #SLCs revealing thousands of new links.

Metabolic mapping of the human solute carrier superfamily | Molecular Systems Biology imageimageThe large collection of SLC perturbation cell lines enables parallel assessment of changes in metabolites and transcripts and the first systematic survey of the metabolic consequences of SLC...

Clustering and integration of metabolomics and transcriptomics profiles of all #SLCs enabled the linkage of #SLCs to new metabolic pathways. Further experimental validation uncovered roles in osmolyte balance and glycosylation doi.org/10.1038/s443...

Photographed in Hexham market square, On the left we have Jack Moffat, northeast engagement manager for Thomas pocklington trust stood next to on the right is Hexham town councillor Trevor Cessford

It was great to be joined by councillor Cessford for our walk around Hexham today, highlighting a few key issues faced with the built environment within the town and we look forward to addressing these together.
@SLCouncils @daftladtc #VisionForChange #SLCs

I’m a lil late😅 but does my #slcs (slightly-late cock Saturday) work? 😈😂