Anticodon-edited transfer RNAs (ACE-tRNAs) encoded as therapeutic nonviral minimal DNA vectors Abstract. Nonsense mutations, resulting from a premature termination codon (PTC), make up ∼11% of all genetic lesions causing disease, affecting millions o

Excited for our most recent study that does a deep dive into therapeutic minivectors that express ACE-tRNAs for treatment of nonsense-associated diseases. The method development here was years in the making. Check it out at NAR! #nonsense #tRNAs #therapeutics #NAR

doi.org/10.1093/nar/...

Next up in our LongTREC video series is Leda Katopodi!

Leda is doing exciting research at @crg.eu, working with
@evamarianovoa.bsky.social
to explore the role of epitranscriptomic modifications of #tRNAs in cancer and beyond!

#CancerResearch #tRNAs #RNAMods #Epitranscriptomics

#culo #trnas #ts

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

A new study in #ScienceMagazine this week reports Specific #tRNAs promote #mRNA decay by recruiting the CCR4-NOT complex to translating #ribosomes
www.science.org/doi/10.1126/...