APC24-7, a covalent combination of boronic acid and chelator moieties, restores β-lactam efficiency against metallo-β-lactamase-producers | mSphere The ability of bacteria such as Klebsiella pneumoniae and Escherichia coli to circumvent antimicrobial chemotherapy has become a global public health crisis. The high prevalence of β-lactamase enzymes...

Interested in #β-lactamase inhibitors? 🧪

Our new #mSphere paper shows how a covalent boronic-acid + chelator fusion ⚗️ can restore β-lactam susceptibility in metallo-β-lactamase producers, even in variants that are difficult to inhibit with #taniborbactam.

journals.asm.org/doi/full/10....