Perspective on yeast-3-hybrid assays for target identification of bioactive natural products - Phytochemistry Reviews While an immense number of natural products have been screened for bioactivity using a variety of phenotypic assays, elucidation of their protein targets remains a significant bottleneck limiting furt...

Happy to share a new paper from our group! A short and sweet overview on yeast 3-hybrid for target ID of bioactive natural products

Useful for anyone interested in protein targets of their hit compounds, while being easy and economical to set up

#secmet #natprod #targetid
doi.org/10.1007/s111...

Chemical proteomics for a comprehensive understanding of functional activity and the interactome Traditional mass spectrometry (MS)-based proteomics aims to detect and measure protein expression on a global scale and elucidate the link between protein function and phenotypic characteristics. Alth...

It is Gold Open Access paper, so everyone can check it out. It is quite extensive work so I want to thanks to Kostia for his great contributions.

doi.org/10.1039/D5CS...

#chemoproteomics #targetID #PPI #Interactome #chemicalpharmacology