#Thyroidology ‘Year in Review’ to kick off #ATA2025 starting off with the basic science review! 🦋
Looking forward to reconnecting with old friends and making new ones 😊
[And yes - ChatGPT hallucinates!]
#ENDOSky #MedSky
📚 The @kargerpublishers.bsky.social #Endocrinology Collection on #ScienceOpen features publications that present diverse basic and clinical information across a wide range of topics — including #PediatricEndocrinology, #Thyroidology, #Neuroendocrinology, and #Diabetes.
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@kargerpublishers.bsky.social #Endocrinology offers endocrinologists diverse basic or clinical information. Their publications cover a wide range of topics such as #PediatricEndocrinology, #Thyroidology, #Neuroendocrinology as well as #Diabetes: www.scienceopen.com/collection/K...
(A, B) Reliability of SPINA-derived parameters is higher than that of measured hormone concentrations. Shown are results of Monte Carlo evaluation of SPINA-GT and SPINA-GD based on simulated imprecise hormone assays. Hormone concentrations were modeled in SimThyr 4.0 with different pre-defined values for GT and GD, respectively. Subsequently, absolute hormone levels were converted to measurements by means of an S script that injected additive and multiplicative noise in order to get vendor-reported concentration-dependent coefficients of variation (CV). The lines show the mean SD of hormone concentrations predicted by structure parameters calculated from simulated noisy measurements. CVs as markers for measurement reliability of SPINA-GT and SPINA-GD are below 10% in all cases, although CVs of corresponding hormone assays exceed 20% in low concentrations. (C) SPINA-GT is sensitive for thyroid disorders of primary origin and specific with respect to secondary dysfunction. The plots show the distribution of hormone concentrations in certain primary and secondary thyroid conditions compared to normal percentiles of SPINA-GT. The green crossing rectangles define univariate reference ranges for TSH and FT4, respectively. The purple lines represent FT4 concentrations at the 2 and 97% percentiles of SPINA-GT. (D) SPINA-GD is an estimate for deiodination. Shown is the correlation between SPINA-GD and conversion rate in slow tissue pools.
Calculating #SPINA-GT, #thyroid's secretory capacity, and #SPINA-GD, total #deiodinase activity, is evolving towards a standard method of research in #thyroidology, as shown by more than 100 citations of one of our defining papers. 🧪🩺
pubmed.ncbi.nlm.nih.gov/27375554/
doi.org/10.3389/fend...
