Experts Question Evidence for New Testosterone Advice New federal dietary guidance includes advice on boosting testosterone levels, which clinicians say is only partially rooted in evidence.

“‘Testosterone health’ is a “nonsense statement"

My story for @medscape.com

#Medsky #Endosky #supplements #hormones #diet #nutrition #Foodpyramid #endocrinology #obesity #weightloss

GLP-1 Receptor Agonists.

www.nejm.org/doi/full/10....

@nejm.org
#CardioSky #MedSky #Cardiology #EndoSky #GLP1RA

Every form of type 2 #diabetes begins, & ultimately converges, within the biology of the #islet. When that convergence is complete, the story of diabetes will no longer be a dissonance but an islet harmony that connects mechanism to meaning www.thelancet.com/journals/lan... #T2D

#MedSky #EndoSky

Association between GLP-1 receptor agonist use and worsening mental illness in people with depression and anxiety in Sweden: a national cohort study For anxiety and depression that co-occur with diabetes and obesity, semaglutide and, to a lesser extent, liraglutide might be useful dually effective therapeutic options. Randomised controlled trials ...

Published in @thelancetpsych.bsky.social

Association between #GLP-1 receptor agonist use and worsening #mental #illness in people with #depression and #anxiety in Sweden: a national cohort study www.thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky #PsychSky

The association between 10-year cardiovascular risk and fracture incidence in postmenopausal women: a prospective analysis from the Women's Health Initiative A higher 10-year predicted CVD risk was associated with higher MOF and hip fracture risk after adjustment for sociodemographic, lifestyle, and clinical factors. CVD risk may have implications for frac...

Published in @lancetrh-americ.bsky.social

The association between 10-year #cardiovascular risk and #fracture incidence in #postmenopausal #women: a prospective analysis from the Women's Health Initiative www.thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky #CardioSky #RheumSky

Specific cortisol blockade in Cushing's syndrome Cushing's syndrome is most frequently seen in patients on exogenous glucocorticoids (ie, steroids) for immune-related conditions (eg, rheumatoid arthritis and asthma) and specific haematological cance...

Ashley Grossman comments on:
Specific cortisol blockade in #Cushing's syndrome thelancet.com/journals/lan...
#hypercortisolism #hypertension

#MedSky #EndoSky

Efficacy and safety of relacorilant for the treatment of patients with Cushing's syndrome (GRACE): a multicentre, phase 3, double-blind, placebo-controlled, randomised-withdrawal study Patients treated with relacorilant were more likely to maintain hypertension control compared with patients treated with placebo. The findings support consideration of relacorilant as a therapeutic op...

Patients with endogenous #hypercortisolism of various causes given #relacorilant during the randomised-withdrawal phase were 5·9 times more likely to maintain #hypertension response compared with those who received placebo thelancet.com/journals/lan...
#Cushing's syndrome

#MedSky #EndoSky

The key points from the Review Article "Clinical Implications of Minipuberty"

A new review by Anders Juul, MD, DMSc, PhD, summarizes the current understanding of minipuberty and describes its potential clinical implications. Read the full review: nej.md/3PZhsap

#MedSky #PedSky #EndoSky

#Endocrine #complications occur in 40–60% of survivors of #cancer and include hypothalamic–pituitary disorders, dysregulation of steroid and peptide hormones, and dysregulation of bone and metabolism thelancet.com/journals/lan...
#OpenAccess

#MedSky #EndoSky #OncSky

Aberrant hormone receptors regulate a wide spectrum of endocrine tumors Aberrant G-protein coupled receptor (GPCR) expression is highly prevalent in cortisol-secreting primary bilateral macronodular adrenal hyperplasia (PBMAH) and unilateral adenomas. The aberrant express...

Aberrant or ectopic hormone receptors and their ligands play a much wider role than appreciated in regulating hormonal secretion via endocrine, paracrine, and autocrine modes in many #endocrine #tumours thelancet.com/journals/lan...
#GPCRs

#MedSky #EndoSky #OncSky

Osteopenia: a key target for fracture prevention Osteopenia was originally a qualitative term denoting bone that appeared to be less dense on radiographs. Since 1994, it has also had the quantitative meaning of a bone mineral density (BMD) T-score b...

Although patients with #osteoporosis are generally at higher #fracture risk than are patients with osteopenia, most fractures occur in the larger group of adults with #osteopenia www.thelancet.com/journals/lan...
#BoneHealth

#MedSky #EndoSky #RheumSky

The potential role for artificial intelligence in fracture risk prediction Osteoporotic fractures are a major health challenge in older adults. Despite the availability of safe and effective therapies for osteoporosis, these therapies are underused in individuals at high ris...

Clinical integration of AI–ML algorithms has the potential to transform #osteoporosis management, offering a more personalised approach to reduce the burden of osteoporotic #fractures www.thelancet.com/journals/lan...
#ArtificialIntelligence

#MedSky #EndoSky #RheumSky

Beyond the heart: the urgent need for a dementia-forward diabetes agenda The clinical practice of diabetes management has undergone a paradigm shift over the past two decades. GLP-1 receptor agonists and SGLT2 inhibitors have expanded the therapeutic focus beyond glycaemic...

Linked Comment:
Beyond the #heart: the urgent need for a #dementia-forward #diabetes agenda www.thelancet.com/journals/lan...
#T2D #CVD

#MedSky #EndoSky

Mortality from #cardiovascular disease and #diabetes has declined among people with diabetes in most jurisdictions, whereas mortality from #dementia has increased markedly, independent of age www.thelancet.com/journals/lan...
#T2D #CVD

#MedSky #EndoSky

The increasing number of men presenting with functional #hypogonadism poses diagnostic challenges due to subtle clinical features and controversies in diagnostic serum #testosterone cut-offs www.thelancet.com/journals/lan...
#MensHealth

#MedSky #EndoSky

Although weight loss in people with #obesity has many health benefits, it can also have adverse #skeletal effects, with increased #bone loss and #fracture risk thelancet.com/journals/lan...
#osteoporosis #weightloss #GLP-1 receptor agonists #BariatricSurgery

#MedSky #EndoSky #RheumSky

Osteoporosis in men is a common but often overlooked disorder by clinicians www.thelancet.com/journals/lan...
#osteoporosis #MensHealth

#MedSky #EndoSky #RheumSky

The typical patient with #hyperthyroidism is a woman of reproductive age with symptoms such as nervousness, heat intolerance, palpitations, and weight loss despite increased appetite www.thelancet.com/journals/lan...
#thyroid

#MedSky #EndoSky

New—Artificial intelligence for interpreting diabetes data using clinician-curated benchmarks www.thelancet.com/journals/lan...
#diabetes #CGM #AI
#FREE to read

#MedSky #EndoSky

Prevalence of early-stage type 1 diabetes in young adults: a population-based cohort study Type 1 diabetes was once thought to be exclusively a childhood-onset disease, but recent epidemiological evidence shows that more than half of all clinical diagnoses of type 1 diabetes occur in adulth...

New—Prevalence of early-stage type 1 diabetes in young adults: a population-based cohort study www.thelancet.com/journals/lan... #T1D
#FREE to read

#MedSky #EndoSky

Re-evaluating the concept of remission in type 2 diabetes: a call for patient-centric approaches Controlling weight and cardiovascular risk factors is paramount in type 2 diabetes management; however, the definition and feasibility of remission warrant closer examination. Type 2 diabetes remissio...

By re-evaluating current definitions, acknowledging the progressive nature of type 2 #diabetes, and embracing individualised approaches to glycaemic control, #remission can be redefined as a dynamic continuum rather than a static endpoint www.thelancet.com/journals/lan... #T2D

#MedSky #EndoSky

When the Scale Isn’t the Whole Story: Three Principles for Practicing Person-Centered Obesity Care - Endocrine News Zeb I. Saeed, MD, a member of the steering committee for the Endocrine Society’s Early Career Special Interest Group (SIG), shares with clinicians three patient-centric principles to treating overweig...

Zeb I. Saeed, MD, a member of the steering committee for the endocrinesociety.bsky.social Early Career Special Interest Group, shares with clinicians three patient-centric principles to treating #overweight and #obesity. #endocrinology #EndoSky

endocrinenews.endocrine.org/when-the-sca...

Tyrosine kinase inhibitor (TKI)-induced thyroid hormone abnormalities result from interference with the #HPT axis and peripheral #thyroid #hormone metabolism regulators thelancet.com/journals/lan...
#hypothyroidism #TKIs

#MedSky #EndoSky #OncSky

The hypothalamic–pituitary–thyroid axis plays a crucial role in the pathogenesis, diagnosis, risk stratification, effectiveness of #radioiodine therapy, and treatment response evaluation in epithelial #thyroid #cancer thelancet.com/journals/lan...
#HPT axis #thyroidcancer

#MedSky #EndoSky #OncSky

Can artificial intelligence bridge the gaps for primary diabetes care in low-income and middle-income countries? Artificial intelligence (AI) has the potential to improve primary diabetes care in low-income and middle-income countries (LMICs), where the rising burden of disease contrasts sharply with limited hea...

By aligning technological innovation with health care needs, #AI could evolve from a proof-of-concept tool to a practical enabler of equitable, scalable, and cost-effective #diabetes care in low-income and middle-income countries www.thelancet.com/journals/lan...
#ArtificialIntelligence

#EndoSky

The incidence and prevalence of thyroid eye disease (#TED) have presumably declined in the last decades, possibly related to more attention given to risk factors (eg, smoking) and faster diagnosis and earlier treatment of #Graves' #hyperthyroidism www.thelancet.com/journals/lan...
#thyroid

#EndoSky

Review Article Clinical Implications of Minipuberty Anders Juul, M.D., D.M.Sc., Ph.D. An illustrated diagram of the hypothalamic–pituitary–gonadal (HPG) hormone axis in male infants, children, and adolescents.

A new review discusses minipuberty, a transient phase in infancy during which levels of gonadal hormones are similar to those in adults, after which they become undetectable until the onset of puberty. Read the full review: nej.md/3PZhsap

#MedSky #PedSky #EndoSky

Endocrine Society endorses bipartisan bill to address insulin affordability The Endocrine Society today endorsed the Improving Needed Safeguards for Users of Lifesaving Insulin Now (INSULIN) Act, a bipartisan bill to address insulin affordability introduced by Sens. Jeanne Sh...

Endocrine Society endorses bipartisan bill to address insulin affordability. bit.ly/4sRllx3 #diabetes @endocrinesociety.bsky.social #EndoSky

In the past three decades, there has been growing recognition of the complex interplay between mental health and physical health among people with #diabetes www.thelancet.com/journals/lan...
#T1D #T2D #GDM #mentalhealth

#MedSky #EndoSky #PsychSky

Redifferentiation therapy in unresectable or metastatic radioactive iodine refractory thyroid cancer: an International Thyroid Oncology Group statement In patients with follicular cell-derived thyroid cancer that have distant metastases and no iodine uptake, redifferentiation—ie, the restoration of tumoural 131I uptake with systemic therapy—is now po...

In patients with follicular cell-derived #thyroid #cancer that have distant metastases and no iodine uptake, #redifferentiation—ie, the restoration of tumoural 131I uptake with systemic therapy—is now possible www.thelancet.com/journals/lan...
#thyroidcancer
#OpenAccess

#MedSky #EndoSky #OncSky