Trevi Therapeutics Reports Fourth Quarter and Year End 2025 Financial Results and Provides Business Updates  Following the End-of-Phase 2 meeting with the FDA, the Company gained alignment on its Phase 3 program for the treatment of patients with idiopathic pulmonary fibrosis-related chronic cough On track to initiate a Phase 2b clinical trial for the treatment of patients with refractory chronic cough in

#TRVI Trevi Therapeutics Reports Fourth Quarter and Year End 2025 Financial Results and Provides Business Updates 

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Trevi Therapeutics Announces Publication of Data from the Phase 2b IPF Chronic Cough Trial of nalbuphine ER in the Journal of the American Medical Association (JAMA) Trevi Therapeutics (Nasdaq: TRVI) announced that key Phase 2b CORAL trial results for oral nalbuphine ER in idiopathic pulmonary fibrosis (IPF) chronic cough were published in JAMA on Jan 22, 2026. The trial showed a statistically significant reduction in 24-hour objective cough frequency across all dose groups at Week 6, with significant effects as early as Week 2. More than 60% of treated patients achieved ≥50% reduction in 24-hour cough frequency at Week 6. Patient-reported outcomes aligned with objective monitoring. Safety was consistent with prior data; discontinuations due to adverse events were 6% in treated groups versus 5% for placebo.

#TRVI Trevi Therapeutics Announces Publication of Data from the Phase 2b IPF Chronic Cough Trial of nalbuphine ER in the Journal of the American Medical Association (JAMA)

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Trevi Therapeutics Reports Second Quarter 2025 Financial Results and Provides Business Updates Trevi Therapeutics (NASDAQ: TRVI) reported significant achievements in Q2 2025, highlighted by positive Phase 2b CORAL trial results for Haduvio™ in treating chronic cough in IPF patients. The trial demonstrated statistically significant reductions in 24-hour cough frequency across all dose groups, with the highest dose (108mg BID) achieving a 60.2% reduction from baseline (p<0.0001).The company successfully completed a $115 million underwritten offering in June 2025, ending Q2 with $203.9 million in cash and equivalents, extending runway into 2029. Q2 financial results showed R&D expenses of $9.4 million (down from $10.0 million in Q2 2024) and a net loss of $12.3 million. The company plans to request an End-of-Phase 2 FDA meeting in Q4 2025 and aims to initiate Phase 3 trials in H1 2026.

#TRVI Trevi Therapeutics Reports Second Quarter 2025 Financial Results and Provides Business Updates

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