Day 7: Poor evidence re neuropsychiatric effects of #varenicline. Outlined in a post-marketing observational cohort study were:mood swings, depression, hallucinations, changed libido as uncommon events & psychosis noted ‘rare’ (not exhaustive). Risk ↑ if history of psych illness; warn accordingly

Day 6: #varenicline has no known clinically signif drug-drug interactions. A putative interaction with alcohol, namely ↑ intoxication effects is not established. Can use with nicotine replacement products, but advice needed pre use with other cessation meds as can ↑ risk of ADEs eg psych disorders

Day 5: Common ADEs for #varenicline include GI disorders, muscle/joint disorders, headache, skin reactions, sleep disorders. Mood change, sexual dysfunction & seizure are all 'uncommon'. Angioedema & SCARs are rare (NOT exhaustive)

Day 4: #varenicline is a partial nicotine receptor agonist which has its greatest effect in the CNS. Binding leads to controlled dopamine release, alleviating craving & withdrawal. By preventing nicotine itself binding, #varenicline reduces the reinforcing effects of nicotine/lessens addiction

Day 3: #varenicline (cont). Severe renal impairment may require dose adjustment & consideration should be given to the effect of smoking cessation on kinetics of other drugs eg olanzapine, clozapine, theophylline

Day 2(cont) #varenicline can be continued to support abstinence @ same dose for further 12 weeks

Day 2: #varenicline is a tablet licensed as smoking cessation aid for 18+. Started when person is still smoking & once therapy established, they stop smoking after 1-2 weeks. Titration up to 1mg twice daily; Days 1-3, 500 micrograms o.d, Days 4-7, 500 micrograms b.d. Treatment course 12 weeks

Day 1: An alkaloid extract from the Laburnum tree, cytisine was used in E.Europe/known for mild impact on smoking cessation. Exploration of structural analogues with better efficacy led to #varenicline discovery. FDA/EMA approved as a stop smoking aid in 2006

New drug series '7 days of #varenicline' starting today

Leeds pharmacists to prescribe smoking cessation medication under PGD Pharmacists in Leeds are set to prescribe smoking cessation medication under a patient group directive (PGD) to address the local area’s lack of access to the drugs. Leeds City Council is…

Leeds City Council is commissioning pharmacists to prescribe #varenicline and #cytisinicline to smokers looking to quit, with a target start of May 2026

#smokingcessation #stopsmokingservices

buff.ly/mtqSTYd

Healthy Plant-based Eating Reduces Health Disease Risk by nearly HALF. #vaping #teens #chantix #varenicline #cessation

The Tobacco Smoking Cessation Drug Chantix Helps Your Teen Stop Vaping. This according to a Harvard Mass. General study. #vaping #teens #chantix #varenicline #cessation

Baseline predictors of smoking cessation among individuals with current or past major depressive disorder following treatment with varenicline and intensive behavioral treatment In a 2 × 2 factorial clinical trial with 300 individuals with current or past major depressive disorder (MDD), varenicline significantly increased smo…

#Varenicline #SevrageTabac en 1ere intention si #EtatDepressifMajeur 🔽🔽
www.sciencedirect.com/science/arti...
@scouraud.bsky.social @alicedeschenau.bsky.social @sfalcoologie.bsky.social

Quitting Smoking? You've got options.
If NRT is not your thing, #Varenicline is another highly effective option. Talk to your healthcare provider to see what’s right for you.

Learn more about Varenicline: shorturl.at/VpGFR

Varenicline for Youth Nicotine Vaping Cessation This randomized clinical trial evaluates the efficacy of varenicline plus behavioral counseling, compared with placebo plus behavioral counseling or with enhanced usual care (behavioral counseling alo...

Vareniclina, combinada con consejos conductuales, aumenta la abstinencia al vapeo en jóvenes que vapean nicotina que no fuman tabaco regularmente #varenicline #vaping jamanetwork.com/journals/jam...

EBM BLS: E-Cigarettes and Varenicline are Both Effective for Smoking Cessation

The #BottomLine from @societyGIM:
E‑Cigarettes and #Varenicline are Both Effective for #SmokingCessation

Read in #JGIM:

How can newly available medications support the progress of Stop Smoking services?

#Varenicline #Cytisine #Cytisinicline #StopSmoking #SmokingCessation #PharmSky #MedSky

Clinical consequences of varenicline shortage: A study on the French national pharmacovigilance database Clinical consequences of varenicline shortage: A study on the French national pharmacovigilance database

Pharmacovigilance
Clinical consequences of varenicline shortage: A study on the French national pharmacovigilance database
#DrugShortage #Varenicline #Smoking #Cessation #Therapy #Pharmacovigilance
www.em-consulte.com/article/1732...

Smoking cessation drug to be provided on NHS three years after its withdrawal over carcinogen concerns Smoking cessation drug varenicline will be made available again for NHS patients, three years after it was withdrawn owing to fears over a probable carcinogen, NHS England has announced. In a statemen...

I hope there will be a standardised patient group directions #PGD for prescribing generic #varenicline to increase the uptake for #smokers who are will to quit #NHS #NHSE #SmokeFreeGeneration #SmokingCessation

pharmaceutical-journal.com/article/news...