#H5N1 #AvianInfluenza #Panzootic #OneHealth #Spillover #ViralEvolution #FoodSecurity #GlobalHealth #Biosecurity
References
Grijalva-Trejo & Vasquez, 2026. www.liabjournal.com/index.php/li...
Gwon et al., 2026. doi.org/10.3390/ani1...
10/11
🧬🦁 New research shows SARS-CoV-2 can rapidly evolve after jumping from humans to zoo animals.
A rare Delta variant spilled over into tigers, then spread to lions and hyenas
Read the full story: www.news-medical.net/news/2025121...
#SARSCoV2 #ViralEvolution #Genomics #ZooScience #COVID19Research
New Insights Into Arterivirus Receptor Usage and Tropism November 18, 2025 Adam Bailey, M.D., Ph.D. University of Wisconsin–Madison David Levy, Ph.D. (moderator) NYU Grossman School of Medicine Felicia Goodrum, Ph.D. (host) Co-Editor in Chief, Journal of Virology, Geisel School of Medicine at Dartmouth
They infect mammals worldwide—but, so far, not humans. 🧬
Join Dr. Adam Bailey on Nov. 18 at 10 a.m. ET for a free webinar on new insights into arterivirus receptor usage and host interactions. asm.social/2Fj
#Virology #ViralEvolution #Research #JVI #Arterivirus
A Man Had COVID For 750 Days Straight and His Body Became an Incubator For Virus Evolution #Science #HealthandMedicine #InfectiousDiseases #COVID19 #ViralEvolution
8/14 Evolution continues: As H5N1 spreads among cows, cats, and other animals, virus mutation risk increases.
"The probability of mutation or reassortment events that could support human-to-human transmission" grows with each infection, experts warn.
#ViralEvolution
🦠 New research reveals that 8% of the human genome is composed of ancient viral fragments, highlighting the deep evolutionary connection between humans and viruses. Link: https://tinyurl.com/23mgvqqb #Genomics #ViralEvolution #HumanBiology
Viral adaptation is a major theme: a universal antiviral could rapidly drive viruses to evolve resistance, mirroring the challenge of antibiotic resistance in bacteria. Viruses are incredibly resilient. #ViralEvolution 4/6
8/12 The research reveals viral evolution trade-offs:
Rigid protein conformations = higher infectivity but allow immunity to work faster
Flexible conformations = immune escape but potentially lower binding efficiency
#ViralEvolution
8/11 Scientists found one intriguing detail: H5N1's neuraminidase protein shares 89.6% amino acid identity with seasonal H1N1, suggesting possible partial protection through conserved epitopes.
But antibody tests detected none.
#ViralEvolution
Comparative benchmarking of viral phylogeography methods reveals how different models reconstruct spatial spread under varied outbreak scenarios
#Phylogeography #ViralEvolution #BioinformaticsMethods
👤EVBC: Simon Dellicour, Philippe Lemey, Sebastian Lequime
🔗
#H5N1 #H5Nx #AvianInfluenza #Reassortment #ViralEvolution #OneHealth #Panzootic
📚 References:
🔹 Baxter et al., 2025. doi.org/10.1101/2025...
🔹 Gong et al., 2025. doi.org/10.1371/jour...
12/12
🧬 GVAtlas Reveals Mutation Shifts in SARS-CoV-2 Membrane Gene Post-Vaccine Rollout
🔗 Access: gvatlas.org
🛰️ Powered by GVAtlas: Empowering global genomic surveillance with actionable, open-access datasets.
#GVAtlas #SARSCoV2 #MutationReport #Mgene #ViralEvolution #COVID19 #HerdImmunity
Wu Lab at Rowan University unveils a better method for studying adaptation: the c/µ test. It works on UTRs, accounts for synonymous mutations, and avoids false positives. Implications for viral evolution studies. go.njmicrobe.org/Up7l2R #Genomics #ViralEvolution #MolecularBiology
Super-pangenome analysis of 3562 human and animal papillomavirus isolates illuminates their genome and pathogenicity evolution
Chen, C., Chen, J. et al.
Paper
Details
#ViralEvolution #PapillomavirusResearch #SuperPangenomeStudy
#H5N1 #InfluenzaA #GenomicSurveillance #ViralEvolution #OneHealth #BirdMigration #Spillover #ScienceAdvances
📚 Signore et al., 2025
Science Advances, 11(28): eadu4909
🔗 doi.org/10.1126/scia...
(12/12)
3/12 Researchers identified 62 unique H5N1 genotypes in Canada alone.
The virus extensively reassorted with local low-pathogenic influenza viruses, creating novel combinations that challenge traditional understanding of viral evolution.
#ViralEvolution #Reassortment
9/10 Even with optimal preparation, experts expect surprises."
This H5 virus has taught us that these viruses are always one step ahead of us," warns researcher Sorrell.
The evolution continues, whether we're ready or not.
#ViralEvolution
2/10 Virologist Anice Lowen from Emory University raises alarming concerns about vaccines that limit disease but don't prevent infection.
Such approaches could allow H5N1 to continue replicating and evolving while appearing controlled.
#Vaccines #ViralEvolution
2/12 Two new H5N1 genotypes emerged in the US:
• B3.13 (March 2024) - cattle-adapted strain
• D1.1 (January 2025) - more severe human illness
These "reassortant" viruses combine deadly bird flu genes with local influenza, creating unprecedented pandemic threats.
#ViralEvolution #Genotypes
🦠 SARS-CoV-2's sneaky evolution decoded! Viral variants outsmart immune defenses through strategic gene shifts. 🧬 Genomic detective work reveals how COVID adapts & survives. 🔬 #ViralEvolution #Genomics #ScienceBreakthrough https://emmecola.github.io/genomics-daily
The impact of clade B lineage 5 MERS coronaviruses spike mutations from 2015 to 2023 on virus entry and replication competence
Lau, K. K., Peiris, M. et al.
Paper
Details
#MERSvirus #SpikeMutations #ViralEvolution
📣@inrae-france.bsky.social publie son rapport d'activité 2024. #agriculture #biodiversité #oneHealth #ClimateChange
🔗www.inrae.fr/actualites/rapport-dacti...
👍Retrouvez les faits marquants de nos recherches en pages 31 et 40 de ce rapport : #ViralEvolution #DiseaseControl 👍
2/5
Why care about BA.3.2?
Most variants differ from their ancestors by just a few spike mutations. BA.3.2, however, shows extensive spike divergence - likely from long-term infection of an immunocompromised patient.
#ViralEvolution
2/9 The 2023 grey seal H5N1 strain killed ferrets within 3 days.
In stark contrast, the older 2005 Indonesian strain allowed all test animals to survive until at least day 4.
This accelerated mortality represents a concerning evolution in viral pathogenicity.
#ViralEvolution
8/9 THE MUTATION CONCERN:
As a researcher noted: "We'll never catch up with Mother Nature. We're never gonna catch up with the virus and how it mutates."
Goal is detecting mutations that make virus "more mammalian adaptable" before it's too late.
#MutationRace #ViralEvolution #MammalianAdaptation
3/12 THE 1997 BREAKTHROUGH: Everything changed when a 3-year-old boy in Hong Kong died from H5N1.
"We didn't expect to see high-path avian influenza viruses infecting humans. We just didn't expect that."
Scientists thought bird and human flu were separate
#HongKong1997 #H5N1History #ViralEvolution
2/9 The virus has a dark history. First detected in 1996, H5N1 spread globally through migratory waterfowl, mutating into diverse clades.
Clade 2.3.4.4b emerged in 2016, reaching Canada by 2021—with an ominous new trait: infecting marine and terrestrial mammals.
#AvianFluenza #ViralEvolution
2/7 The virus emerged through genetic mixing last summer in the southwestern Baltic Sea. Six gene segments came from the dominant EA-2021-AB strain, but two crucial polymerase pieces originated from low-pathogenicity viruses circulating in wild birds.
#ViralEvolution
repository for influenza sequences - and a key platform during the COVID-19 pandemic, centralizing SARS-CoV-2 genomic data.
In the next post, we’ll explore how H5N1 reached North America, drove up egg prices, and surprised the world by infecting cattle
#H5N1 #Virology #ViralEvolution #GISAID (9/10)
Current VOCs are spreading via increased transmissibility or fitness rather than immune evasion!
Read clinical brief at:
tahirhb.com/GVAtlas
#ViralEvolution
#SARSCoV2Variants
#Transmissibility
#ViralFitness
#VariantSurveillance
#PublicHealth
#VirusAdaptation
