Original post on med-mastodon.com

“the scientists show how an adenovirus protein triggers “rogue” antibodies in people with an unlucky combination of genetic background and a particular mutation in their antibody-producing B cells. Instead of targeting a viral protein, the rogue antibodies bind to PF4, setting off a dangerous […]

Free Nucleic Acids in the ChAdOx1 nCov-19-S Adenovirus Vector Vaccine Contribute to an Anti-platelet Factor 4 Antibody Response - PubMed Vaccination against SARS-CoV-2 was instrumental in controlling the COVID-19 pandemic. Rare cases of vaccine-induced immune thrombocytopenia and thrombosis (VITT) emerged following vaccination with the adenovirus vector-based vaccines ChAdOx1 nCov-19-S and Ad26.COV2.S. VITT is mediated by high-titer …

pubmed.ncbi.nlm.nih.gov/41183547/

If anyone is interested in understanding the proposed mechanism behind VITT in connection with the AstraZeneca vaccine, this article offers a solid overview.
- free DNA in the vaccine formulation
#vaccine #VITT

Why Adenovirus COVID Vaccines Caused Blood Clots (And What It Means) Adenovirus vaccine blood clots were caused by a rare misdirected immune response called vaccine-induced immune thrombotic thrombocytopenia, or VITT. New research in the New England Journal of Medicine shows that in people with specific immunoglobulin light-chain gene variants, IGLV3-21*02 or *03, antibodies first raised against an adenoviral core protein, pVII, can acquire a somatic mutation that shifts binding to the human protein PF4, activating platelets and triggering clots.

Curious why some adenovirus COVID vaccines led to rare clots? It traces to a misdirected immune response (VITT). See what scientists found—and what it could mean for future shots. What questions do you have? #adenovirus #COVID19 #PF4Antibodies #vaccines #VITT

#SVT #Hirnvenenthrombose #SARSCoV2 #Covid19 #Vektorimpfstoff #VITT #HIT #PF4 Rätsel gelöst (?)

Monoclonal Anti–Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss | NEJM Two patients with monoclonal anti-PF4 antibodies, thrombosis, and chronic thrombocytopenia also had first-trimester pregnancy losses, findings that suggest a possible link between these antibodies ...

💡 Monoclonal Anti–Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss @nejm.org
➡️ 2patients with monoclonal anti-PF4 antibody–mediated thrombosis, chronic intermittent thrombocytopenia, and unexplained first-trimester pregnancy losses
#VITT #VITTlike
www.nejm.org/doi/full/10....

Thrombosis UK led patient involvement in the thrombosis with thrombocytopenia syndrome consortium, formed to deepen understanding of the syndrome post vaccination. Report now available thrombosisuk.org/wp-content/u...
#VITT @bhwords

Anti‐PF4 mediated thrombocytopenia and thrombosis associated with acute cytomegalovirus infection displays both HIT‐like and VITT‐like characteristics Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is one of several anti-platelet factor 4 (anti-PF4)-associated immune thrombocytopenia and thrombosis (PITT) syndromes. As well as follow...

🚨 New VITT-like report from 🇬🇧 in the contextof CMV infection and anti-PF4 paraprotein 🧐

#VITT #MGTS

onlinelibrary.wiley.com/doi/10.1111/...

🤦🏻‍♂️Donc en 2025, on doit encore expliquer l'absence de lien entre vaccin ARNm COVID-19 et thrombose.
🙏🏼Merci à @afpfactuel.bsky.social de faire ce travail de factchecking et de m'avoir permis de clarifier les choses 🔍
#VITT #COVID19 #FakeNews @afpfr.bsky.social

factuel.afp.com/doc.afp.com....

https://doi.org/10.1056/NEJMoa2415930 No description available

Chronic prothrombotic disorders linked to VITT-like monoclonal gammopathy show anticoagulant-refractory thromboses & intermittent thrombocytopenia. #VITT PMID:39938091, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2415930 #Medsky 🧪

VITT-like Monoclonal Gammopathy of Thrombotic Significance | NEJM Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is associated with antibodies that target platelet factor 4 (PF4) and are heparin-independent. VITT antibodies are implicated in acute,...

www.nejm.org/doi/10.1056/...

"Vaccine-induced immune thrombocytopenia and thrombosis ( #VITT) is associated with antibodies that target platelet factor 4 (PF4) and are heparin-independent."

New blood-clotting disorder identified Researchers at McMaster University have made a discovery in the field of hematology, providing an explanation for spontaneous and unusual blood-clotting that continues to occur despite treatment with ...

New blood-clotting disorder identified #PF4 #VITT #MECFS #LongCovid

medicalxpress.com/news/2025-02...

Blood clots tied to vaccines can also occur spontaneously, scientists find The discovery has shed light on a complex blood interaction that has likely always been present in humans but was unnoticed until recently

Blood clots tied to vaccines can also occur spontaneously, scientists find, by @ivansemeniuk.bsky.social www.theglobeandmail.com/canada/artic... via @theglobeandmail.com #VITT #COVID19

VITT-like Monoclonal Gammopathy of Thrombotic Significance | NEJM Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is associated with antibodies that target platelet factor 4 (PF4) and are heparin-independent. VITT antibodies are implicated in acute,...

Very happy to be part of this international collaboration 🇨🇦🇫🇷🇪🇸🇳🇿🇩🇪 defining the VITT-like Monoclonal Gammopathy of Thrombotic Significance @nejm.org

@hopitalpompidou.bsky.social
@hopitalcochin.bsky.social
@upcite.bsky.social

www.nejm.org/doi/full/10....

#VITT #AntiPF4 #Thrombosis

Vitt | Dikt om färgen vit i form av frost –Poeten .se Vitt är en haiku i en serie om färger av poeten Iréne Svensson Räisänen. ”Vad är vitt för dig? Är den ens en färg, eller?”

Jag har skrivit första dikten i en serie om färger ”Vitt”: poeten.se/dikter/vitt-...
Hur många färger finns det? Hmm...

#vitt #dikt #haiku #vit #frost #färger #färgdikter #poesi #lyrik #poetenirene

Relevance of anti-PF4/H antibodies and platelet activation in systemic inflammatory diseases and thrombosis disorders: insight from the COVID-19 pandemic The increased interest in anti-platelet factor 4 (PF4)-heparin complex (anti-PF4/H) antibodies following the COVID-19 pandemic has established them as crucial players in immunothrombosis. We aimed to ...

🥳 New findings from our group on anti-PF4/H antibodies during #COVID19 and post #vaccination ! #HIT #VITT @rpth.bsky.social 📰

🔗 www.rpthjournal.org/article/S247...

@davidmsmadja.bsky.social @terrierben.bsky.social
@upcite.bsky.social @hopitalpompidou.bsky.social

😵Just discovered what may be the first case of a VITT-like condition following an infection in a young patient was French 🇫🇷, reported in 2010 and published in a French journal. You can translate the article for more information. #antiPF4 #VITT #HIT

🔗 pubmed.ncbi.nlm.nih.gov/21159583/

#Rügen Fischerdorf #Vitt #KapArkona heute Abend im Lande von @meteohro.bsky.social #Wetter Nix Badewetter derzeit .

Visst passar dessa tre färger enormt bra ihop? #himmelsblått #vitt #guld #treenighet

A complete report of the #VITT UK cases from our haematology colleagues (https://www.nejm.org/doi/full/10.1056/NEJMoa2109908 confirms #CVST as the most common site of thrombosis and #ICH as the most serious complication.

Collaboration gets us further.

When the first cases of #CVST #VITT emerged, the UK neurologists, stroke physicians and haematologists came together to investigate them.
This paper @TheLancet is the outcome of our work and the largest cohort of such patients to date.

Rapid review on CVST in the context of #VITT in the @wfneurology Journal of Neurological Sciences:
- summary of reports
- differences from 'standard' CVST
- need for multidisciplinary management

#openaccess at: https://bit.ly/2RBGEGi