Design of differential expression analysis in clusters between APOE E4+ and E2+ donors. Bar plot of number of DEGs from each cluster in SRT and snRNA-seq data, subcluster Oligo.3 had the majority of DEGs.

To explore gene expression changes in AD risk, we performed differential expression analysis with #voomLmFit on ERC clusters between high risk #APOE E4+ and low risk E2+. We found a large number of differential expressed genes in an oligodendrocyte subcluster Oligo.3 #edgeR #limma