Pirto+ven R/R WM/LPL #ASH25
- 38 pts, 29 completed 6 cycles (total 24)
- ORR 100%, VGPR/CR 56%
- lower RR if CXCR4mut, TP53mut, prior cBTKi
- 12-mo PFS 94%
- MYD88wt pts (n = 2) w/ early PD
Great all oral option for MYD88mut R/R WM. #lymsm #wmsm

Home | United States | PROMISE Study: Researching Multiple Myeloma See if you qualify for a study screening to detect early indicators of blood cancer known as multiple myeloma. Visit The Promise Study now, part of Dana-Farber Cancer Institute. We're seeking voluntee...

Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE) - www.promisestudy.org @PromiseStudy #NCT03689595 #mmsm #wmsm #precisionprevention US adults, age 40-75, qualify for a free screening: 1. African Americans and/or 2. 1st degree relative w/ MM, MGUS, SMM, WM

Multiomics analysis of IgM monoclonal gammopathies reveals epigenetic influence on oncogenesis via DNA methylation [Sep 19, 2024] @KLChohan et al. @BloodJournal
ashpublications.org/blood/articl... #lymphoidneoplasia #wmsm

Pneumococcal vaccine [PCV7 & PPV] responses in elderly Pts w/ MM, WM, MGUS [Oct 11, 2013] Karlsson et al. Trials in Vaccinology ow.ly/G4tzH #geriheme #mmsm #wmsm #IDonc More research needed into vax biology in B cell malignancies

Comparative study of immune status to infectious agents in elderly patients with multiple myeloma, Waldenstrom's macroglobulinemia, and monoclonal gammopathy of undetermined significance - PubMed Whereas patients with multiple myeloma (MM) have a well-documented susceptibility to infections, this has been less studied in other B-cell disorders, such as Waldenstrom's macroglobulinemia (WM) and ...

Pneumococci, staphylococcal alpha-toxin, tetanus & diphtheria toxoids, varicella, mumps, & rubella viruses - Antibody titers : MM < WM < MGUS < controls [2011] Karlsson et al. Clin Vaccine Immunol ow.ly/wTYz30iYZs3 #IDonc #mmsm #wmsm

Paper: Characterizing Genomic Variants Defining a Plasma Cell Disorder Patient Cohort Using a Broad Next Generation Multi-Gene DNA Sequencing Panel

Characterizing Genomic Variants Defining a Plasma Cell Disorder Pt Cohort Using a Broad Next Generation Multi-Gene DNA Sequencing Panel [Dec 8, 2024] Ezell et al. - @UConn #ASH24 Abst 3314 ash.confex.com/ash/2024/web... #mmsm #wmsm n=158 PCD samples incl MGUS, SMM, MM, WM etc