📰 News flash - www.nytimes.com/2026/04/17/h...

My hat is more than it seems.

It’s made from #mushroom #mycelium, the fine, fibrous network that weaves through soils across the world, connecting #ecosystems beneath our feet.

This is why we use mycelium in Host Defense products.

See mushroomreferences.com for the latest information.

Honoring our Mentors Giving Gratitude to those who have led us

Honoring our #Mentors
Giving #Gratitude to those who have led us

❤️ Looking back on my life, I realize how certain people shaped me in ways I only truly appreciate years later—and it’s made me reflect more deeply on my own journey. Here’s some thoughts.

🔗 paulstamets.substack.com/p/honoring-o...

These developments in policy and research set an important precedent for how these therapies can be responsibly integrated. More to learn as this evolves!

#FungiSky #Mycelium #Mushrooms #Health

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This month, New Mexico allocated $630,000 to create the first #medical #psilocybin equity fund in the US, aiming to ensure access regardless of income.
At the same time, legislation is advancing in Massachusetts, & King County, Washington has moved to support research/deprioritize enforcement.

1/2

This research builds on decades of work studying #Agarikon (Fomitopsis officinalis), one of the rarest #medicinalmushrooms. We now have 120 strains of Agarikon in culture, in pursuit of identifying a potential “super strain” for #pandemic defense.

Read more: www.bio-itworld.com/news/2026/03...

3/3

Published in BMC #Immunology, the study found the #fungal combination was safe, reduced vaccine side effects, and did not compromise #antibody response, with antibody levels sustained and in some cases increased at six months.

2/3

Hi 🍄 folks!

At the #IMC27, I shared results from our placebo-controlled randomized clinical trial with @ucsandiego.bsky.social & the Krupps Center for Integrative Research, led by Gordon Saxe, MD, PhD, studying #Agarikon and #TurkeyTail #mycelium alongside #mRNA #COVID19 vaccination.

1/3

I built my company to fund this kind of research. This milestone belongs to the scientists, the team & to everyone who believed #fungi could help change the trajectory of #humanhealth

🙏 Thank you for your support on this long but epic journey.

Please read the study & please share the science.

5/5

For years, conventional medicine has asked for placebo-controlled randomized clinical trials.

💯 This is it.

We now have two clinical studies showing reproducibility. This is another scientific success from our team and a powerful step forward in validating #fungi through rigorous science.

4/5

To our knowledge, this is the 1st placebo-controlled human clinical trial demonstrating a fungal adjunct enhancing vaccine response.
#Immunogenicity increased. #Reactogenicity decreased.

🍄Fungal #mycelium, ancient organisms w/ deep evolutionary intelligence, may offer a scalable, affordable...

3/5

... that was published in BMC Immunology today and highlighted by @ucsandiego.bsky.social, which found that a combination of #Agarikon + Turkey Tail #mycelium used alongside mRNA #COVID-19 #vaccination was safe, reduced vaccine side effects, and did not compromise antibody response.

2/5

📣 In a continuation of our 30 years of research, persistence & millions invested into natural products science, we have another announcement to share.

📰 today.ucsd.edu/story/study-...

📖 link.springer.com/article/10.1...

We supplied this double-blind, placebo-controlled clinical trial...

1/5

... up as #mushrooms surge in popularity. What does the evidence show?
We looked at the efficacy of #mycofermented rice vs rice placebo & data from 2 recent randomized, controlled studies. The takeaway is that #immunesupport is not about overstimulation, but balance.
Thanks to all who joined!

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Hey Folks!

On Feb. 19th, I presented a the Integrative Healthcare Symposium in NYC. I am grateful to have spent time w/ an inspiring community of clinicians & #integrative #health practitioners.
In my talk on #mushroom #mycelium & enhancing immunity, we explored a question that keeps coming...

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*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

TM & © 2026 GDP

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A legendary collab just dropped. 🌈🍄 Grateful Dead Gummies™—a legendary collaboration between Grateful Dead, mayself & Host Defense!

3 groovy organic mushroom mycelium-powered formulas, three distinct vibes, one far-out way to support your wellness.*

Learn more: hostdefense.com/pages/gratef...

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👋 Hi #Myconauts

We did a lot of 🍄 foraging this year, from edible and choice species, to poisonous, and more! Thanks to all of you for coming along for the ride.

Can’t wait to see what fungi we find in 2026 !

#Mycelium #FungiSky #FungiFriends #MushroomSky

... #Mushrooms are complex organisms, and oversimplifying them leads to poor outcomes.
These results track with 2 recent double blinded clinical studies using mushroom #mycelium fermented rice - compared to a rice placebo, post ingestion.

Disclosure: I own Host Defense. The science is solid.

3/3

... The #mycelium extract supported a balanced, adaptable immune response. Under certain conditions, the fruiting body extract increased pro-inflammatory signaling.
As functional #mushrooms move into the mainstream, rigorous science, proper extraction & ingredient standardization are essential.

2/3

📣 New research: Lions Mane #Mycelium out performs Lions Mane Fruitbody.

A new article from Fungi Perfecti and Host Defense compared lion’s mane mycelium and fruiting body extracts, and the #immune responses were notably different.

Link to article: www.supplysidesj.com/immune-healt...

1/3

Neuroscience JUST Did the IMPOSSIBLE YouTube video by Chase Hughes

This work deepens our understanding of how #psilocybin may support mental #health by reshaping large-scale #brain connectivity.

📽️ Watch the video by Chris Hughes to learn more: www.youtube.com/watch?v=lZ3_...

3/3

Neuroscience JUST Did the IMPOSSIBLE YouTube video by Chase Hughes

.... effectively rewiring #neuralnetworks.

📖 As seen in this @cp-cellrepphyssci.bsky.social article: www.cell.com/cell/fulltex...

These changes were network-specific, strengthening pathways tied to perception and the brain’s default mode network, while quieting repetitive #cortical loops.

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📣 A remarkable new study shows that a single high-equivalent dose of #psilocybin in mice can rapidly increase neuroplasticity by repairing and creating new neural connections in the #brain.

Researchers observed structural remodeling of #dendritic spines in the medial #frontalcortex...

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You don’t get to assume #bioactivity from a species name. You test the actual preparation.

www.preprints.org/manuscript/2...

Important #disclaimer so nobody gets weird: this is a preprint and still under peer review. But the direction is clear enough to be interesting, and it reinforces something I’ve been saying for years:

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Also notable: the #mycelium showed stronger #antioxidant and iron-chelating activity than the fruiting-body extract in this setup.

5/7

...extract. Under the same challenge, the fruiting-body extract nearly doubled IL-1β, while the #mycelium drove it down. Same species, different material, different immune outcome. That’s a big deal for anyone who thinks “Lion’s Mane is Lion’s Mane.”

4/7

... #mycelium prep consistently reduced classic stress cytokines like IL-1β, TNF-α, and IL-8, while keeping baseline #cytokines low. In other words: modulate, don’t light the place on fire.

2) Tissue type matters. A lot.
They compared the mycelium to a β-glucan-enriched fruiting-body...

3/7

... and how it behaves in human immune cells under stress. Not a mouse, not a marketing deck. Actual PBMCs, transcriptomics, and cytokine readouts.

Two things jumped out at me:
1) Calm under challenge.
When immune cells were hit with an inflammatory LPS challenge, the Lion’s Mane ...

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