Check out our protocol for streamlined isolation and immunophenotyping of leukocytes from various mouse tissues! Excited to implement these in our in vivo mouse models to better understand the immune system and harness it for safe and effective immunotherapies. @um-radyfhs.bsky.social

Join us for the last CHRIM Research Rounds of the termon Dec 1st! We'll hear from Dr. Yale Michaels and Huda Alfarekh, sharing their presentation "Broadening access to genetically modified cell therapies through cost-effective manufacturing." See you there! #RPOMISE #CHRIM #CCMB

And thank you to the Paul Albrechtsen Research Institute @cancercaremb.bsky.social for supporting my attendance through the Dr. Leigh Murphy Manitoba Tumour Bank Travel Award!

Highlights from a wonderful #CCRC2025. Thank you to the organizers for the opportunity to give a lightning talk on our work in creating better and safer CAR T cell therapies.

It was a fruitful 3 days of networking and great science! The future of cancer care is alive in 🇨🇦

Interested in using single cell technologies to unravel the molecular origins and evolution of ovarian cancer?

We are looking for a graduate student! More details here 👇

National Letter Open Letter from Canadian Researchers to the Federal party leaders Click here to sign this letter See who has signed - version française se trouve à page 3 - Dear Party Leaders We, the undersigne...

If you are a Canadian Researcher, faculty member, RA, PDF or graduate student in Canada please consider signing our letter to ask for increase of funding in research to make Canada a leader in science and build a stronger economy.

docs.google.com/document/d/1...

Team Manitoba at BioCanRx Summit for Cancer Immunotherapy 2025

Thank you BioCanRx Cancer Stakeholder Alliance for inviting me to participate in this year's Learning Institute! I couldn't think of a better way of celebrating #DaffodilMonth than with my #TeamManitoba Patient Scholars, Sandra and Cynthia 💛🩷💚

...Meghan Kates' award-winning HQP plenary talk on immuno-metabolism, Dr. Livnat Jerby's @stanford.edu groundbreaking synbio technologies, and the plenaries ending on a high note with Dr. Denis Migliorini's novel CAR designs for high-grade gliomas.

My personal favourites from this year's Summit included:
Dr. Katy Rezvani's @mdanderson.bsky.social scientific keynote on their amazing translational discoveries on CAR-NK, Milan Heck's eye-opening patient partner keynote, Shannon Snelling's wonderful patient-grad student partnership program...

This plenary was concluded by Dr. Christian Hinrichs @rutgerscancer.bsky.social who presented their progress in utilizing cell therapies against HPV-related epithelial cancers.

HQP Leanne Palichuk (Lee Lab
@ucalgary.bsky.social) talked about her work on utilizing rare DN T cells to improve the potency of anti-tumour T cells against relapsed pediatric AML.

Then, Dr. Marie Bleakley
@fredhutch.bsky.social featured their innovative work on TCR T cells against minor histocompatibility antigens for patients who relapse post-HSCT.

First, Dr. Doug Mahoney @ucalgary.bsky.social presented on their Canadian clinical trial using GCAR1 CAR T cells, which target GPNMB on sarcomas.

Sandra (my Patient Scholar) and I were tasked to present on Plenary 1: Clinical Testing of Innovative T cell Therapies for Cancer. This thought- (and hope-) provoking plenary highlighted novel T-cell therapies and their progress towards clinical utility.

This year, we had 5 outstanding plenaries on T cell therapies, non-T players of the immune system, immuno-metabolism, spatial immunobiology, and mRNA-based immunotherapies.

That's a wrap for this year's BioCanRx #Summit4CI! Here are some "bites" from Canada's Immunotherapy network from the lens of a Learning Institute Scholar— a thread. #oncosky #cansky #immunosky

Thanks @umbmg.bsky.social! Looking forward to connecting with folks attending #BioCanRx #Summit4CI this weekend!

Design of sensitive monospecific and bispecific synthetic chimeric TCRs for cancer therapy @naturecancer.bsky.social @sylvainsimon.bsky.social
www.nature.com/articles/s43...

It's 𝗜𝗻𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝗼𝗻𝗮𝗹 𝗗𝗮𝘆 𝗼𝗳 𝗪𝗼𝗺𝗲𝗻 𝗮𝗻𝗱 𝗚𝗶𝗿𝗹𝘀 𝗶𝗻 𝗦𝗰𝗶𝗲𝗻𝗰𝗲. I only know because this is being shared a lot across all platforms.

Vaccination against hepatitis B can help prevent liver cancer in children, against human papillomavirus (HPV) in young girls can help prevent cervical cancer later in life.

Today is #WorldCancerDay

Did you know❓

Vaccination against #hepatitisB can help prevent liver cancer in children, while #HPV vaccination for young girls can reduce the risk of #CervicalCancer later in life.

Learn more 👉bit.ly/2NeFF8B

Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies in 783 Patients (38 clinical trials)
-Analysis in 169 patients = no pathological insertions linked to secondary malignancies
-Highlights safety of vector gene engineered T cell therapies www.nature.com/articles/s41...

Happy holidays, Tamra!

A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing - Nature Cell Biology Werbowetski-Ogilvie, Taylor and colleagues report a noncanonical role for OTX2 in regulating alternative splicing and controlling a stem cell and pro-tumorigenic splicing program in group 3 medullobla...

#NCB2024
In July, @tamraogilvie.bsky.social, Taylor, @olivier-saulnier.bsky.social & co reported a noncanonical role for OTX2 in regulating #AlternativeSplicing and a stem cell and pro-tumorigenic splicing program in group 3 #medulloblastoma.
www.nature.com/articles/s41...

Max Rady College of Medicine | University of Manitoba - Department of Biochemistry and Medical Genetics Biochemistry is the study of the chemistry within all living organisms. Through innovative research and scholarship, we are working to understand, prevent and treat disease, including genetic disorder...

The Department of Biochemistry and Medical Genetics at the University of Manitoba is excited to join BlueSky!

Follow us for updates on our groundbreaking research, departmental achievements, and latest developments in the field!

Find out more about more here: umanitoba.ca/medicine/dep...

🧬

Hello! We are the Pediatric Research in Oncology in #Manitoba: Innovation, Science, Excellence (PROMISE) theme, a dedicated research group established through the Children's Hospital Research Institute of Manitoba (CHRIM) and CancerCare Manitoba (CCMB).

I've made a starter pack for the department of Biochem and Med Genetics at the University of Manitoba Rady Faculty of Health Sciences. Comment if you'd like me to add you. Please feel free to share with others.

go.bsky.app/PH1RXXX

Let's build a starter pack for childhood cancer research.
Please send a message to be added! 🎗️
go.bsky.app/Tpd9QnM

Hi Olivier- would love to be added!🎗️

Both #Cancer #Research starter packs are now completely full!

~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️

I hope you'll find these useful to build our community here

Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA