This is Callie. She is trained to accurately detect bowel cancer in order to provide rapid diagnoses through non-invasive testing. Some might call it lab work, but Callie is actually a sprocker spaniel. 14/10 incredible job, Callie (IG: medicaldetectiondogs)
Join our mailing list for early access to AI-driven drug discovery insights & breakthroughs through the #OpenBind initiative. https://loom.ly/Vro7Lo8
Issue 21 highlights:
Paxilin’s nuclear switch in the brain
RING E3s reading & extending ADPr-ubiquitin
Review: Decoding immunometabolism
Nuclear actin limits chromatin leakage upon migratory squeeze
Cover by @syncellbiolab.bsky.social: unlike Odin-archael FtsZ twins
www.embopress.org/toc/14602075...
Read our November issue!
Featuring testing olorofim to treat fungal infections, introduction of nirsevimab for RSV in Chile, and new oxazolidinones for tuberculosis therapy.
www.thelancet.com/issue/S1473-...
Roberto Matta, "The Bachelors Twenty Years Later", 1943
Philadelphia Museum of Art
Roberto Matta on La Mariée Mise à Nu par ses Célibataires, même: "Painting - glass - mirror - these are the three substances in the dynamic interrelation to the final image of the Glass...
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Daily Piece of Art
🎨 Roberto Matta 🇨🇱 (1911 - 2002)
🖼️ On the Edge of a Dream (1956) - oil on canvas
#art #painting #surrealism
Gift of Mr. and Mrs. Armand P. Bartos
The Pike (La Pique)
https://botfrens.com/collections/111/contents/1156260
Perspective from Richard McIntosh describing the history of research on #microtubule polymerization in terms of the ideas, technologies, and observations that have emerged as countless researchers have studied the dynamics of these essential cytoskeletal polymers. rupress.org/jcb/article/...
Solomon R. Guggenheim Museum, New York Solomon R. Guggenheim Founding Collection © 2016 Artists Rights Society (ARS), New York/ADAGP, Paris
Levels by Vasily Kandinsky, 1929
https://botfrens.com/collections/212/contents/137781
Previously unknown contacts between mitochondria identified using new approach with AI & volumetric electron microscopy
📹 Benjamin S. Padman, Runa S.J. Lindblom & @lazaroulab.bsky.social, @monashuniversity.bsky.social @jcb.org
➡️ bpod.org.uk/archive/2025/10/3 with
@antdlewis.bsky.social
Solomon R. Guggenheim Museum, New York © 2016 Artists Rights Society (ARS), New York/ADAGP, Paris
Years of Fear by Matta, 1941 #artbots #guggenheim
https://botfrens.com/collections/212/contents/137917
Nike co-founder Phil Knight and his wife Penny Knight have pledged to donate $2 billion to Oregon Health & Science University’s Knight Cancer Institute, the school announced Thursday, describing it as the largest single gift to a U.S. university.
apnews.com/article/ohsu...
A stars massive outburst captured by the Hubble Space Telescope.
Credit: NASA/ESA
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
Natural compounds from turmeric and rhubarb have demonstrated potential to inhibit multidrug-resistant bacteria in wastewater, suggesting a possible strategy to address antibiotic resistance.
Critically endangered leopard caught on camera in Bangladesh forest: "Extremely rare and secretive species" cbsn.ws/4esfOX1
Top: Schematic of GP2 filaments, with labeled residue ranges of ZP domains and four N-glycosylation sites. Middle left: Cryo-EM map of GP2 filaments, color-coded according to the schematic above. The density of one of the flexible branches was indicated by a black arrow. Middle right: Atomic model of GP2 filaments, with five N-glycosylation sites marked by arrows. Bottom: Proposed model of GP2 filaments’ function in the digestive tract. The filament core of UMOD and GP2 is colored in dark blue and green, respectively. The EGF domains and D8C/D10C domains in the branches of both proteins are shown in grey and light blue, respectively. High-mannose N-glycans are colored in red. UPEC cells and their adhesive pilus are colored in pink, while the proteases (such as elastase) are colored in yellow.
#Glycoprotein 2 (GP2) filaments protect against infections by acting as decoys for the bacterial #lectin FimH. The #cryoEM structure of GP2 filaments provides insights into filament assembly and #antibacterial function in the digestive tract @plosbiology.org 🧪 plos.io/3HP2obF
Solomon R. Guggenheim Museum, New York Gift, Fuller Foundation, Inc., 1976 © 2016 Artists Rights Society (ARS), New York/ADAGP, Paris
Blue Painting by Vasily Kandinsky, 1924 #artbots #guggenheim
https://botfrens.com/collections/212/contents/137152
Isaac Asimov on, "If God is Dead, Everything is Permitted?"
“Dog chases down ambulance that owner is being transported in. When EMS realise, they let the dog in.”
Love this 🥰❤️
#DogSky
#Reddit
r\NextF***ingLevel
Tubulin rings induced by cryptophycin show compacted longitudinal interfaces #TubulinTuesday
"This was an experiment by a kindergarten class. They dropped seeds in the cracks of the sidewalk to see what would happen.
This would help our bees "
via I Love Bees
What are the molecular targets of inhaled anesthetics, such as isoflurane? Hideaki Ueda &co @riken-bdr.bsky.social @utokyoofficial.bsky.social report that isoflurane binds type 1 ryanodine receptor, which can be targeted to modulate sensitivity to #anesthesia. 🧪
plos.io/45EsVlx
Cryogenic light microscopy of vitrified samples with Angstrom precision www.biorxiv.org/content/10.1101/2025.05.27.656160v1 #cryoEM
Structure of blood cell-specific tubulin and demonstration of dimer spacing compaction in a single protofilament pubmed.ncbi.nlm.nih.gov/39725029/
How sad!
Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍
Preprint📜: www.biorxiv.org/content/10.1...
A short thread🧵👇
