The cell biology community mourns the loss of Catherine Rabouille, an exceptional scientist whose determination, innovation, and fearless engagement with ideas reshaped how we think about cellular organization. #InMemoriam from @adamgrieve.bsky.social and colleagues: rupress.org/jcb/article/...

📢 Next Proteostasis Consortium Seminar – Tomorrow, Wednesday 4 February 2026 at 4:00 pm GMT (10:00 am CT)

Speaker: David Glass (Regeneron Pharmaceuticals)

Title: Proteostatic Mechanisms Involved in Age‑Associated Disease

👉Link & Updates here: www.proteostasisconsortium.com/seminars/

📣 Proteostasis researchers - we want to hear from you!

What techniques, protocols, or assays would you love to learn more about?

👉 Share your ideas in our quick survey (docs.google.com/forms/d/e/1F...)

Add our first pre-print to your reading list?

Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social!

Please share: tinyurl.com/3h8r7f5y

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. www.science.org/doi/10.1126/...

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

This sounds like a fun job!

Grant Cancellation Web Form WAS YOUR GRANT CANCELED BY PRESIDENT TRUMP? The Committee on Science, Space, and Technology, Democratic Staff, is surveying the impact of the Trump Administration’s cancelation of federal research awards. If your award was terminated since January 20, 2025, please fill out this brief survey. If you had multiple awards terminated, please fill out a separate form for each award. While anonymous submissions will be helpful to the Committee’s efforts, we encourage you to leave your contact information if you are open to having a confidential conversation with Committee staff. Please find our confidentiality policies at the following link – any information you share will be treated with these protections, regardless of your current affiliation with any current or former funding agency: https://democrats-science.house.gov/contact/whistleblower

Are you a PI of a federal grant cancelled by the Trump administration?

Please share your info with the Democratic Staff of the House Committee on Science, Space, and Technology, who launched this portal yesterday to track funding cancellations 🔭🧪

forms.office.com/pages/respon...

Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.

🔬 Hiring: Postdoctoral Fellow

Seeking a bioinformatician/screening expert to be part of our team running genome‑wide screens, building data‑integration pipelines & validating hits in higher organisms.

🌱 2‑yr fellowship with tailored mentorship, leadership & science‑communication training

Come and join us in solving mystery of plasma membrane proteostasis in beautiful neurons.

Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!

Announcing the JCS–David Stephens Prize and the 2024 winner Anja Konietzny Over the past 25 years, Journal of Cell Science (JCS) has been awarding a prize of £1000 – ‘The JCS Prize’ – to the first author(s) of the paper that is judged by the Editors to be the best paper publ...

A fitting announcement to an outstanding scientist and friend who is dearly missed by many. journals.biologists.com/jcs/article/...

Protein structure of C1 bound to IgM antibodies

Our new lab website is online!

sharplab.uk

Check it out and learn more about our research in Bristol!

I am recruiting a research assistant. Please send to anyone you know who is interested in gaining more lab experience in host:pathogen interactions of bacterial infections.

www.jobs.cam.ac.uk/job/50738/

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

SO excited to share that a major part of the postdoctoral work in @robzonculab.bsky.social lab is now published: “Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins” www.science.org/doi/10.1126/...

Check out our new paper with Michael Landreh, @pstansfeld.bsky.social and others in @elife.bsky.social : Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization doi.org/10.7554/eLif...

Applications close today for this @uniofmanchester.bsky.social #DigitalNotebook #Metascience project, seasoned with #OpenResearch & served with helpings of #ResearchIntegrity and a side of #ResearchCulture

Full details of everything on the menu below 👇

www.jobs.manchester.ac.uk/Job/JobDetai...

Thank you Ines! I had such a lovely time visiting sunny York this week, sharing our science and chatting cell bio, neuroscience and proteases. Thanks for the invite, special thanks to the one and only @yorkyeast.bsky.social for top-notch hosting!

Toward single-molecule protein sequencing using nanopores Nature Biotechnology - Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing

Nanopore technology might be able to sequence proteins soon! Read about the road ahead in this exciting Perspective rdcu.be/edWPi in @naturebiotech.bsky.social

An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

Do you need some science joy in your life? Do you like neurons? Maybe glia? Molecules? Cell biology? Save the date for #NeuroBioUK25 - the venue is booked and we are excited to see you and your incredible science there on the 12th of September!

neurobiouk.sites.sheffield.ac.uk

An image montage advertising NeuroBioUK - 12th of September 2025 in York. The image is York cathedral superimposed over a fluorescent cortex mouse section coloured to look a bit like a dawn sky.

Save the date: We're excited that the third NeuroBioUK will take place on September. Block it in your calendar to join us in York for a fun day of neurons, glia, cool science and chats!

Macrophages promote collagen deposition through circadian regulation of fibroblasts Collagen deposition in fibroblasts, the primary collagen-producing cells, is regulated by both macrophages and the circadian rhythm, although how these regulatory processes interact with one another i...

Our lab's #1st manuscript from our #1st #PhD Katie is on #bioRxiv! Check it out 👇🏻

#macrophage regulation of fibroblast #collagen #circadian rhythm. #ImmunoECMatrix w/ @profandrewmac.bsky.social @tracyh9494.bsky.social @mcrcellmatrix.bsky.social @mcf-uom.bsky.social

www.biorxiv.org/content/10.1...

Exciting opportunity in the newly minted McMillan lab in Liverpool. Kirsty is a great scientist and a top mentor for students - if you’re looking for a PhD and are interested in trafficking and neurodegeneration, do contact her!

Thanks Loges, very kind of you!

UK Membrane Trafficking 2024

Who doesn’t like a deadline that gets brought forward?

Please register by 3rd December - King’s need longer to make the sandwiches than I previously thought!

estore.kcl.ac.uk/conferences-...

Programme coming soon!

Amazing PhD opportunity to join an exciting new lab at Bristol Biochemistry - send your best students in Ferdos’ direction!

This scheme shows the cargo adaptor FHF in the middle with arrows pointing to distinct microtubule and actin-based motors (dynein-dynactin, KIFC1, KIF1C and myosins V, IX and X as well as Tropomyosin 1). It also shows a link to Rab5 marked early endosomes. The hypothesis is that FHF coordinates multi motor binding at the early stages of endocytosis. The PhD project would address the hierarchy of motor binding and how these motors coordinate to allow the newly formed vesicle to transition from the actin to MT cytoskeletal network.

If you’re interested in how molecular motors coordinate to power intracellular trafficking events (e.g. endocytosis), I’ve got a PhD position available to study this at vibrant Bristol uni. In this project, we will capture highly dynamic events by #cryoEM, single molecule imaging & cell biology. 🔬❄️🧪

Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c

Waves of new BlueSky arrivals in last few days!

I’ve been tracking starter packs relevant to molecular/mechanistic/genetic/cellular…etc biology

Hope it’s helpful but warning: now a v long thread!

Probably the last time I can do this...