All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy?
Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation.
www.nature.com/articles/s41...
(1 out of 3)
Antifungal susceptibility testing across fungi: why MICs vary, methods diverge, and what MIC can miss
Cornelia Lass-Flörl and colleagues
Open access in @cmijournal.bsky.social
www.clinicalmicrobiologyandinfection.org/article/S119... #IDSky #MedMycoSky
As (also) a palliative care doc, this message hit home with me:
“Antibiotics may be beneficial in some cases and should not be denied to patients enrolled in hospice care.”
Sometimes treating active infection improves sxs and is aligned with hospice goals.
academic.oup.com/cid/advance-... #IDSky
As an aside, how do you see these so quickly?!? I heard it here before it was in my email box! 😱
Very interesting. It seems we have also been seeing an increase in KS recently, some in PLWH (though no necessarily with advanced disease) and some without. Some of us have wondered if there is something else going on.
Reports of organ donor–derived Kaposi sarcoma–associated herpesvirus among transplant recipients (n = 46) and investigation of additional recipients* — United States, January 2021–September 2025. * Retrospective KSHV testing of the 46 donors whose organs were associated with posttransplant donor organ KSHV infection identified 25 (54%) who received positive results and four (9%) who received negative results; organs from 17 (37%) donors had not been tested.
Number of reports of suspected organ donor–derived Kaposi sarcoma–associated herpesvirus infections in transplant recipients (N = 57) — United States, January 2010–September 2025
Kaposi Sarcoma–Associated Herpesvirus Infection and Complications Among Solid Organ Transplant Recipients — United States, January 2021–September 2025
New in MMWR
-46 cases of susp donor-derived KS in SOT, vs 9 from 2016–2020
-2/3 donors had a hx of nonmedical drug use
www.cdc.gov/mmwr/volumes...
Exciting research here on the development and lab evaluation of #CRISPR #POC tests for #STIs (chlamydia, gonorrhea, syphilis, HSV 1 /2)
Also very interesting they could detect S91F to predict cipro resistance in #gonorrhea
POC tests for STIs can be game-changers in many settings
#STIsky #IDsky
They are the fire extinguishers of medicine.
The subscription style reimbursement models seem to be a good move. The US just re-introduced the PASTEUR Act (2.0) for this too 🙏🏽 #AMR
My top 10 ID papers for 2025. Full citations and descriptions available at clarityinitiative.org/hot-takes
Also see/hear our Communicable podcast episode on this at communicable.transistor.fm/episodes/com...
What were your top 10? Any thoughts about what I missed welcome!
#IDSky #Top10papers
A doozy of a quote in this profile of the "godfather of vaccines" by @helenbranswell.bsky.social, as he watches his field trend in the wrong direction
“All I can say is that I’m beginning to regret having lived so long — because we’re going downhill,”
www.statnews.com/2026/03/02/s...
New PJI study in @ofidjournal.bsky.social:
Largest restrospective study to date of doxycycline use for PJI treatment with encouraging results
All doxycycline use was in combination though, primarily rifampin. Limited to Staph, Coryne, & Cuti
#IDSky #OrthoID
academic.oup.com/ofid/advance...
We are still accepting applications for our #TID fellowship/advanced training year at UCLA for 2026-27 ☀️ 🌴 - please reach out w any questions about this opportunity! recruit.apo.ucla.edu/JPF10380 #MedEd #IDSky @txidfellows.bsky.social @ast-idcop.bsky.social @idsainfo.bsky.social @idjclub.bsky.social
Good overview of an increasingly rapid-evolving field, including newly updated guidelines, non-antibiotic treatments and focus on quality of life. #UTISky
academic.oup.com/cid/advance-...
WHO now recommends near point-of-care tests, tongue swabs, and sputum pooling for TB diagnosis!
Big advance!!
www.who.int/teams/global...
A case of liver necrosis 2/2 isavuconazole in a patient with genetic mutation leading to low CYP3A5 activity.
😳 Detectable levels 3 months after medication stopped
🤔 Authors suggest ALT/AST testing and TDM in older pts who have longer Isavu courses
#IDSky
academic.oup.com/ofid/advance...
🤨Comparative Effectiveness of 3 Benzathine Penicillin G-Based Regimens in PWH With Early Syphilis #CROI2026
credits @ hivvirology
Very interesting!
Do you know the doxy duration?
Randomized? Couldn't tell from abstract.
Final results from a huge French PrEP study finds both daily and on-demand (aka 2-1-1) oral PrEP are safe and effective for HIV prevention.
#CROI2026
The #GoGoVax 🇦🇺 trial of the #menB vaccine against #gonorrhea among men observed no effectiveness.
Results obviously disappointing, as we need more tools to prevent gonococcal infections, esp as #AMR rises. Some hope for #MAGI study 🙏🏽
#IDSky #STIsky #MedSky #CROI2026
www.healio.com/news/infecti...
Editorial is definitely worth a read - it goes into some of the historical aspects of #syphilis and treatments.
Interesting (but not terribly surprising) to learn that 3-dose regimens were based on very low quality evidence and haven't changed in 50 years! 🤯
academic.oup.com/cid/advance-...
There are shortages of #BPG. Cases of #congenitalsyphilis are surging. A clinical trial of different treatment regimens for late or unk duration #syphilis is desperately needed.
Not only in the US, but in other global settings where access and resources are limited.
#STIsky
Important paper about how we treat #syphilis - are 3 doses of benzathine #penicillin G needed for late or unk duration infections? Using surveillance data, no differences in 1 v 3 doses of BPG (or vs 28d of #doxy) were observed.
We need a trial👇🏽!
#IDsky #STIsky
academic.oup.com/cid/advance-...
#CROI2025 #idsky Twice-Daily Dolutegravir With a 4-Month Rifapentine-Based Regimen for HIV-Associated Tuberculosis presented by Sean Wasserman:
-DTG clearance markedly increased by RPT 1200mg co-administration
-DTG bid dosing with RPT-based TB tx:
therapeutic, safe, achieved Viral suppression
Unfortunate results of the #STOMP trial for #mpox.
We really need therapeutic options for mpox, as infections are ongoing in many communities.
And bravo to the study team - trial data on investigational treatment options are so important.
Great data on pre-transplant serologic testing for fungal infections in the US by my friends at the CDC and @jessicalittlemd.bsky.social #IDSky #MedSky academic.oup.com/mmy/advance-...
This is SUCH a good point. Life now all about being peppered by 100s of parallel mini-conversations by various message platforms.
In clinical space, what does this do? Can we do more things at once? Are we more distracted, and creating risk?
Food for thought for all of us, not just #IDSky #MedSky
Such a good article!
This has become such a big issue recently. Definitely need to plan around, since unlikely going away
Also interesting chats seem more efficient than in-person/phone comm, but I suspect actually take longer to type, read, respond, back-forth etc (+ add constant distraction)
Check out our article and guidance on Epic chat messages in CID. Anyone doing frontline clinical work understands the substantial downsides of constant, on-demand, text communication in the EHR. So great to write this with ID fellows. doi.org/10.1093/cid/...
Brilliant plenary on STI trends at #CROI2026. DoxyPEP implementation in Seattle shows indirect reductions of syphilis rates in cisgender women who are not the target group for the intervention. Shared sexual networks with men who are the target intervention group?
This is concerning on so many levels