Smiling headshot of Matti Pronker
Congratulations to former LMB postdoc @mfpronker.bsky.social, who is launching his own independent research group at Sanquin Research where he'll use protein engineering and structural biology techniques to study important blood protein complexes.
Best of luck to you Matti!
#LMBAlumni
It was a great week in Toronto attending #Hupo2025. Greateful for the opportunity of sharing our work with the world and inspired after so many scientific conversations!
Nobody does anagrams to reveal the true nature of things anymore
Kelly Stecker,
@maltelaar.bsky.social, @hecklab.bsky.social, @vadim-demichev.bsky.social, @coxlab.bsky.social, @slavov-n.bsky.social, @mannlab.bsky.social,
@jespervolsen.bsky.social
Krijgsveld Lab,
Either in person or their online materials / papers were extremely useful!
Life hack: write down stuff you’ve already done on your to-do list and slam a checkmark on it
Doing this for years
Microplastics cross the murine intestine and induce inflammatory cell death after phagocytosis by human monocytes and neutrophils
doi.org/10.1101/2025...
Something to deffinitely have in mind!
I recently discovered Goodreads, and I am so sad I want to read much more books than the ones I have the capacity to actually read atm. #Goodreads #books
Absence of ICAM-1 drives tumor resistance to T and NK cell-mediated killing, with LFA-1 engager molecular potentiating anti-tumor immunity by re-engaging this synaptic interaction @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
T cells acquire both TCRs and CARs from other activated T cells by trogocytosis. Notably, this trogocytosis does not need a cognate receptor/ligand. Modifying CAR transmembrane domains makes trogocytosis more/less likely.
@barbera-stefano.bsky.social et al 2025
www.science.org/doi/10.1126/...
More of these examples are needed
Is a good #FluorescentFriday the best thing ever?? Yes, it is. 👏 #Cellimaging #Research #PhD
🚨 Save the Date! NVMS Spring Meeting 2025, 26th May 🚨
Mark your calendars! 📅 The NVMS Spring Meeting is on 26th May at Sanquin, Amsterdam. Stay tuned for details on abstract submissions and the program. Let's explore the latest mass spec research in the Netherlands! 🔬⚡😀
#NVMS #MassSpec
Despair not (yet)
"If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research."
Really interesting paper 🧪 🤩
Immune evasion through mitochondrial transfer 😮
Ikeda et al find that #mitochondria from cancer cells can #transfer over to T cells - altering their #metabolism & reducing antitumour immunity
www.nature.com/articles/s41...
www.nature.com/articles/d41...
@nature.com
🗺 I'm deeply saddened about the recent government's decisions on science budgets. First NL and then US. Without science, there is no future.
🇪🇦 Sin palabras ante las decisiones de los gobiernos mundiales de cortar la financiacion para investigación cientifica. Sin ciencia no hay futuro.
We built a rust library (rustyms) and the Annotator GUI to analyze any complex bottom-up or top-down peptidoform with any fragmentation based on ProForma 2.0.
Get it on github and read more in the preprint:
www.biorxiv.org/content/10.1...
github.com/snijderlab/a...
github.com/snijderlab/r...
The OT-I TCR is often criticised as being very high-affinity and displaying unusual behaviour compared to other TCR transgenics. New work from @tcell.bsky.social shows this might not be the case. Will I still use OT-I and all the wonderful tools associated with it? Yes I will!
Arte (🇫🇷/🇩🇪 TV channel) just posted a documentary on proteomics on YouTube. Of course somewhat simplified but it’s nice to see our research explained in simple terms for the masses. If you have some time (or want to practice your German), it’s definitely worth watching:
m.youtube.com/watch?v=lVkb...
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus
Now on bioRxiv.
@biorxivpreprint.bsky.social @cusystemsimmu.bsky.social
Had a great day at the 10th anniversary Science for Life meeting. My personal highlights were the incredible #cryoET talk from Julia Mahamid, and @bobcoelingh.bsky.social winning a poster prize! 🏆
🇪🇺I'm honoured to be talking about our work in immuno-oncology proteomics at RadioLibertad España with Antonio Gonzalez Armas
🇪🇦 Agradecida de poder hablar sobre nuestro trabajo en proteomica aplicada a la immunidad antitumoral en Radio Libertad con Antonio Gonzalez Armas
Let's keep sharing science!
REVIEW: Next-generation combination approaches for immune checkpoint therapy
www.nature.com/articles/s41...
@pamsharmamdphd.bsky.social
Different forms of mentoring Image Source: https://frntofficesport.com/wp-content/uploads/2018/02/mentoring-dr.-sara-taylor-1024x784.jpg
Faculty mentoring in academic institutions, a thread.
As I advance in my academic career (read: as I keep getting more gray hair), I've come to appreciate, even more than before, the profound responsibility we (senior-ish faculty) have to support and nurture emerging talent, not diminish it.
An infrared photo of a rainbow: a strange, ghostly-looking rainbow in a mostly black and white photo, with a faintly red outer edge and a cyan inner edge, and what look like a few even fainter ‘echo’ bows inside
A regular visible-light pic of a rainbow
An ultraviolet picture of a rainbow: a dark, foreboding landscape with a deep purple stripe emanating from it, and a grey stripe inside
A composite of the three preceding photos, showing that the infrared bow is ‘outside’ the visible light rainbow, and the ultraviolet bow ‘inside’
There’s more to rainbows than the human eye can see: here’s how a rainbow extends into the infrared and ultraviolet.
Photos:
1. Infrared
2. Visible (obviously)
3. Ultraviolet, and
4. A composite showing how UV is beyond the violet in a rainbow, and IR beyond the red end.
🧪 #photography
PhosX is out! doi.org/10.1093/bioi... Leveraging the latest kinase specificity maps by the Cantley, Yaffe, and Turk labs and a rank sum statistic we created PhosX so now we can predict activities for nearly all kinases in your phosphodata, including the understudied ones. Check it out!
Following the news that eLife will not receive an Impact Factor in 2025, we’ve shared an update on how our model is doing since we were first placed “on hold” by Web of Science, and what we’re up to now. Find out more.
https://buff.ly/3ATRAFT
