Very upsetting to hear the sad news of Greg Hannon’s passing. I always enjoyed our far too few conversations we had over the years. He had an interesting and insightful perspective on any science being discussed. He will be missed. www.cruk.cam.ac.uk/news/in-memo...
Many thanks for this cool collaboration. It is so nice to see the complete story. Love that in vivo work can reveal mechanistic insights, like the MCM2-7 exit gate during helicase activation or the first base pairs that are unwound at replication origins. Well done!
📢 One more week to go... exciting fully funded #PhD position for UK candidates to work across #ICR and #Imperial on novel mechanisms in genome stability and #CancerResearch.
#PhDStudentship #LifeSciences #DNAReplication #CRISPR
🚨 Interdisciplinary PhD opportunity for graduates interested in DNA replication, chromatin biology, and cancer research. Please share with potential candidates.
Thanks Christoph! Have a lovely Christmas and a happy New Year.
We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance.
tiny.cc/vilw001
#PhD #CancerResearch #GenomeStability #Chromatin
Many thanks!
Hi Pedro. Thanks a lot for your reply. We have done an AlphaFold protein interaction screen and wonder if the data are true. Any advice would be greatly appreciated
Blue-sky, I need your help. Is alphafold good in predicting protein-protein interactions involving beta sheets?
A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue.
A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
Still time to apply for the MRC LMS Emerging Innovators Fellowship for scientists of Black heritage!!!
📢To all postdocs. Are you ready to start your semi-independent career? The BBSRC Fellowship call is open. We may host you if you work at the interface of DNA replication/chromatin biology/cancer and like to use protein biochemistry, genomics, cryo-EM, AlphaFold, MD... www.ukri.org/opportunity/...
700,000 women are to be recruited to take part in an NHS AI breast cancer screening trial in England. Five different AI platforms will be tested across 30 sites from April to see if the technology can speed up diagnosis as well as free up radiologists.
www.bbc.com/news/article...
We developed a proteomic kinase activity sensor platform (ProKAS) for the analysis of kinase signaling using mass spectrometry. ProKAS is based on a tandem array of peptide sensors with amino acid barcodes that allow multiplexed analysis for spatial, kinetic, and screening applications.
Excited to share our preprint reporting a completely new approach to study kinase signaling: ProKAS.
ProKAS is based on a tandem array of peptide sensors with barcodes for multiplexed, spatial and kinetic applications.
We applied it to DDR kinases. Please share.
www.biorxiv.org/content/10.1...
Agreed
I was waiting for that...
The Baker Lab (@uwproteindesign.bsky.social) recently hosted this powerful webinar on computational #proteindesign. Take a journey through the history of this groundbreaking field, guided by some of the greats! 🧬🧶 #alphafold #proteomics #proteinscience www.youtube.com/live/BuJGTn7...
Diagram showing archaeal cells containing two chromosomes bound by proteins prior to cell division.
📢 Interested in chromosomes and microbes thriving at the edge of life?PhD project in York-UK on chromosome segregation in #Archaea.
Supervised by me, @Steve Quinn & @georgerheath.bsky.social
www.findaphd.com/phds/project...
Open to Applicants Worldwide!
📅 January 6, 2025
#microsky #archaeasky