Coral microbiomes as reservoirs of unknown genomic and biosynthetic diversity - Nature Reconstructing microbial genomes from 820 reef-building corals collected at 99 reefs across 32 islands throughout the Pacific Ocean highlights the importance of conserving coral reefs as vital reservo...

Now at @nature.com ! Our collab with the Sunagawa lab reveals coral reef microbiomes as a new reservoir for natural product discovery 🪸, and we functionally characterized novel RiPP chemistry and enzymology hidden within these reefs.
Congrats Daniel, Dora, Alena, and Clara on this amazing work!

Widespread hypermodified β-helical peptides in common bacteria Vadakumchery, Meier, Forneris, et al. report a family of β6.3-helical ribosomal peptides that occurs in phylogenetically diverse and well-known bacteria. Their study provides insights into the structu...

Out now in Chem! 🧪
Origamins: hypermodified cryptic peptides with extraordinary structures found in >1000 BGCs including human-associated bacteria.
With potent cytotoxicity they raise fascinating questions about their role in the human microbiome.
Huge congrats to the team and collaborators!🥂

Chemical richness and diversity of uncultivated ‘Entotheonella’ symbionts in marine sponges - Nature Chemical Biology Marine sponges host bacteria that produce diverse bioactive compounds. Here, the authors conduct a large-scale metagenomic, single-bacterial and biochemical study to reveal the untapped biosynthetic p...

Happy to share work by Maria and awesome collaborators published in Nature Chem Bio!
Using metagenomic, single-bacterial, and biochemical methods we provide insights into uncultivated bacterial symbionts as rich sources of bioactive natural products in marine sponges.
#DrugDiscovery #NaturalProducts