Just a reminder: if you're pursuing STEM to stay in academia, the 3 most important skills are: resilience, critical thinking, and effective communication (both written and oral). If you're not ready for that, academic STEM might not be for you.

Carlos Alcaraz wins the #USOpen in 4 sets over Jannick Sinner

US OPEN CHAMPION
WORLD NO.1
𝐂𝐀𝐑𝐋𝐎𝐒 𝐀𝐋𝐂𝐀𝐑𝐀𝐙 👑

#USOpen

Olé tú @carlosalcaraz.bsky.social OLÉ TÚ!!!

Vamos Carlitos!!!

Os digo que me va a dar un parraque esta tarde.

CARLITOS IS BACK IN THE US OPEN FINAL 🗽

#USOpen

Aird Lab

Big day for multiple lab members who celebrated a promotion! Congrats to Apoorva Uboveja for promotion to Staff Scientist and Aidan Cole for starting as a postdoc! I am now a full professor too 🤓 Want to learn more about our science or join the lab? Visit Airdlab.com

Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells Pluripotent stem cells (SCs) rely on metabolic rewiring to regulate self-renewal and differentiation. The hexosamine biosynthetic pathway (HBP) integrates multiple metabolic inputs to produce uridine ...

🎉 We’re excited to share our very first preprint!! 🎉
"Metabolic Crossroads: AMDHD2 Couples the Hexosamine Biosynthetic Pathway to Acetyl-CoA Homeostasis in Pluripotent Stem Cells"
👉 doi.org/10.1101/2025...

#FirstPreprint #StemCells #Metabolism #Epigenetics #AcetylCoA #HBP #Pluripotency #NewScience

I've been playing this gsme after work all week, and it's honestly really relaxing ❤️

Polvorones la Estepeña. Traditional Spanish christmas cookies.

I found this in Lidl… there were only two boxes left, so I took both. You guys can't imagine how much I missed this! I know it's August (and these are Christmas cookies), but I’ll probably finish both boxes before Monday

The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming Cellular senescence, characterized by a stable cell cycle arrest, is a well-documented consequence of several widely used chemotherapeutics that has context-dependent roles in cancer. Although senesce...

The summer has been busy! Along with the move and a PhD defense, we have updated two preprints:
www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

In the second, we discovered that cisplatin drives ovarian cancer metastasis through a metabolic cross-talk between senescent cancer cells with non-senescent cancer cells. We identified fructose as the upstream driver of this phenotype. First author Dr. Cole just defended!

In the first, @raquelbuj.bsky.social discovered that tumors can respond to anti-PD1 without T cells! Mechanistically, this is through a zinc-dependent increase in macrophage phagocytosis, and this is driven through cancer cell CDKN2A-mediated zinc compartmentalization.

We asked metal band frontman Klaus about Tiny Bookshop’s release tomorrow: "Yo, I’m so excited for their big break! Can’t believe there’s only 1 day left… Oh, I’m starting to feel a little stage fright, now that I think about it...”
Meet Klaus at your Tiny Bookshop TOMORROW, 7 pm CEST, on Steam!!!

Every-single-time

Mitochondrial origins of the pressure to sleep - Nature Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

Beautiful and inspiring work from Gero Miesenböck and colleagues www.nature.com/articles/s41...

Myeloid-targeting immunotherapies overcome inhibitory barriers in immune-evasive neuroblastoma This study describes a Mycn-nGEMM for neuroblastoma. Murine and human neuroblastomas showed profound immunosuppression mediated by PD-L1–expressing, TAMs.

Myeloid-targeting immunotherapies, particularly anti-PD-L1, significantly enhance survival in mice with immune-evasive neuroblastoma by remodeling the tumor environment.

by Ménard M, Yoda H (...) Weiss WA et 17 al. in J Exp Med #MedSky

👉 get more here

📖 read the article:

Ozzy Osborne
1948 - 2025

This is a super neat story! Many congrats!!!!

SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation Cell Death & Disease - SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation

Happy to see this fantastic paper by @mela-virus.bsky.social and her lab at @cimususc.bsky.social in which we have collaborated, finally published in Cell Death & Disease, “SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation”:
rdcu.be/evZx9

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
www.science.org/doi/10.1126/...
@science.org @ruthfranklinlab.bsky.social @rmedzhitov.bsky.social

This book is a plagiarism of a Spanish TV series that premiered in 2015 on Spain's public television network, with the exact same name. The author claims she was inspired by the series, but if you watch the show and read the book, it's a very exact kind of inspiration.

A plate made out of wood, with de society for dev bio logo, 2025 Trainee Science Communication Award, my name, and "In recognition of extraordinary science communication and outreach efforts as a trainee member of the Society"

Extremely honored to receive this prize from @socdevbio.bsky.social, which recognizes not only my love for developmental biology, but the extremely online I am 🧪 (protect science, protect people, viva la dev bio!)

Enhorabuena!!!! Te mereces este y otros 50 más!

CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor–driven proteome through PARP7 activity | PNAS PARP7 is an enzyme that uses donor substrate NAD+ to attach a single ADP-ribose moiety onto proteins related to immunity, transcription, and cell g...

Our new paper is out! Trying to understand the molecular function of the PARP7, a PARP family enzyme with links to innate immunity and environmental toxins response. Congrats to Andrii and the rest of the team and collaborators.
www.pnas.org/doi/10.1073/...

I pipetted today
To know if I still can
I focused on what’s in the tip
The only thing that’s real

Here's a baby otter to start your week.

Spaniards have won 18 of the last 24 French Opens 🇪🇸

◽️ Rafael Nadal — 14
◽️ Carlos Alcaraz — 2
◽️ Juan Carlos Ferrero — 1
◽️ Alberto Costa — 1

www.nytimes.com/athletic/641...

Carlos Alcaraz had beautiful words for Jannik Sinner after beating him in the longest Roland Garros final in history

“I’m just really happy to be able to make history with you in this tournament, in other tournaments. You’re a huge inspiration for young kids and for everyone. And for myself.” 🥹